PDE4C

PDE4C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QYM
Identifiers
Aliases	PDE4C, DPDE1, phosphodiesterase 4C
External IDs	MGI: 99556 HomoloGene: 20256 GeneCards: PDE4C
Targeted by Drug
ibudilast, rolipram[1]
Gene ontology Molecular function • phosphoric diester hydrolase activity • protein binding • 3',5'-cyclic-nucleotide phosphodiesterase activity • hydrolase activity • metal ion binding • 3',5'-cyclic-AMP phosphodiesterase activity Cellular component • extracellular fluid • cytosol • cell projection • primary cilium • cilium Biological process • cAMP catabolic process • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5143	110385
Ensembl	ENSG00000105650	ENSMUSG00000031842
UniProt	Q08493	Q3UEI1
RefSeq (mRNA)	NM_000923 NM_001098818 NM_001098819	NM_201607 NM_001310465
RefSeq (protein)	NP_000914.2 NP_001092288.1 NP_001092289.1	NP_001297394.1 NP_963901.1
Location (UCSC)	Chr 19: 18.21 – 18.26 Mb	Chr 8: 70.72 – 70.75 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

cAMP-specific 3',5'-cyclic phosphodiesterase 4C is an enzyme that in humans is encoded by the PDE4C gene.^[4]

Tissue localisation

PDE4C is predominantly found in peripheral tissues.^[5]

References

1. "Drugs that physically interact with cAMP-specific 3',5'-cyclic phosphodiesterase 4C view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. "Entrez Gene: PDE4C phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)".
5. Zhang, HT (2009). "Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs". Current Pharmaceutical Design. 15 (14): 1688–1698. doi:10.2174/138161209788168092. PMID 19442182.

Further reading

• Engels P, Sullivan M, Müller T, Lübbert H (1995). "Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C).". FEBS Lett. 358 (3): 305–10. doi:10.1016/0014-5793(94)01460-I. PMID 7843419.
• Milatovich A, Bolger G, Michaeli T, Francke U (1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse.". Somat. Cell Mol. Genet. 20 (2): 75–86. doi:10.1007/BF02290677. PMID 8009369.
• Bolger G, Michaeli T, Martins T, et al. (1993). "A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs". Mol. Cell. Biol. 13 (10): 6558–71. doi:10.1128/mcb.13.10.6558. PMC 364715. PMID 8413254.
• Obernolte R, Ratzliff J, Baecker PA, et al. (1997). "Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis". Biochim. Biophys. Acta. 1353 (3): 287–97. doi:10.1016/s0167-4781(97)00080-8. PMID 9349724.
• Owens RJ, Lumb S, Rees-Milton K, et al. (1998). "Molecular cloning and expression of a human phosphodiesterase 4C". Cell. Signal. 9 (8): 575–85. doi:10.1016/S0898-6568(97)00072-7. PMID 9429761.
• Sullivan M, Olsen AS, Houslay MD (2000). "Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND". Cell. Signal. 11 (10): 735–42. doi:10.1016/S0898-6568(99)00037-6. PMID 10574328.
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.
• Pérez-Torres S, Miró X, Palacios JM, et al. (2001). "Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H]rolipram binding autoradiography. Comparison with monkey and rat brain". J. Chem. Neuroanat. 20 (3–4): 349–74. doi:10.1016/S0891-0618(00)00097-1. PMID 11207431.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Johnson JM, Castle J, Garrett-Engele P, et al. (2004). "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays". Science. 302 (5653): 2141–4. doi:10.1126/science.1090100. PMID 14684825.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.