PGAP1

PGAP1
Identifiers
Aliases	PGAP1, Bst1, ISPD3024, MRT42, SPG67, post-GPI attachment to proteins 1
External IDs	MGI: 2443342 HomoloGene: 41605 GeneCards: PGAP1
Gene ontology Molecular function • nuclease activity • phosphoric ester hydrolase activity • hydrolase activity • hydrolase activity, acting on ester bonds Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • endoplasmic reticulum Biological process • embryonic pattern specification • nucleic acid phosphodiester bond hydrolysis • head development • attachment of GPI anchor to protein • sensory perception of sound • forebrain regionalization • transport • protein transport • GPI anchor biosynthetic process • myo-inositol transport • anterior/posterior axis specification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80055	241062
Ensembl	ENSG00000197121	ENSMUSG00000073678
UniProt	Q75T13	Q3UUQ7
RefSeq (mRNA)	NM_024989 NM_001321099 NM_001321100	NM_001163314 NM_175508
RefSeq (protein)	NP_079265.2 NP_001308028.1 NP_001308029.1	NP_001156786.1
Location (UCSC)	Chr 2: 196.83 – 196.93 Mb	Chr 1: 54.47 – 54.56 Mb
PubMed search	[1]	[2]
Wikidata

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Post-GPI attachment to proteins 1 is a protein that in humans is encoded by the PGAP1 gene.^[3]

Function

The protein encoded by this gene functions early in the glycosylphosphatidylinositol (GPI) biosynthetic pathway, catalyzing the inositol deacylation of GPI. The encoded protein is required for the production of GPI that can attach to proteins, and this may be an important factor in the transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi. Defects in this gene are a cause of mental retardation, autosomal recessive 42.

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: Post-GPI attachment to proteins 1". Retrieved 2016-04-04.

Further reading

• Tanaka S, Maeda Y, Tashima Y, Kinoshita T (2004). "Inositol deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p". J. Biol. Chem. 279 (14): 14256–63. doi:10.1074/jbc.M313755200. PMID 14734546.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.