PJA1

PJA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L0B
Identifiers
Aliases	PJA1, PRAJA1, RNF70, praja ring finger ubiquitin ligase 1
External IDs	MGI: 1101765 HomoloGene: 129620 GeneCards: PJA1
Gene ontology Molecular function • zinc ion binding • ligase activity • protein binding • metal ion binding • ubiquitin protein ligase activity Cellular component • cytoplasm Biological process • protein catabolic process • protein ubiquitination Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64219	18744
Ensembl	ENSG00000181191	ENSMUSG00000034403
UniProt	Q8NG27	O55176
RefSeq (mRNA)	NM_001032396 NM_022368 NM_145119	NM_001083110 NM_001290555 NM_001290556 NM_008853
RefSeq (protein)	NP_001027568.1 NP_071763.2 NP_660095.1	NP_001076579.1 NP_032879.2
Location (UCSC)	Chr X: 69.16 – 69.17 Mb	Chr X: 99.47 – 99.47 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

E3 ubiquitin-protein ligase Praja1 is an enzyme that in humans is encoded by the PJA1 gene.^[3][4]

Interactions

PJA1 has been shown to interact with UBE2D2^[3] and MAGED1.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Yu P, Chen Y, Tagle DA, Cai T (May 2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics. 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID 12036302.
4. "Entrez Gene: PJA1 praja 1".
5. Sasaki, Aya; Masuda Yoshiko; Iwai Kazuhiro; Ikeda Kyoji; Watanabe Ken (Jun 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". J. Biol. Chem. United States. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. ISSN 0021-9258. PMID 11959851.

Further reading

• Mishra L, Tully RE, Monga SP, et al. (1997). "Praja1, a novel gene encoding a RING-H2 motif in mouse development". Oncogene. 15 (19): 2361–8. doi:10.1038/sj.onc.1201405. PMID 9393880.
• Fang S, Jensen JP, Ludwig RL, et al. (2000). "Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53". J. Biol. Chem. 275 (12): 8945–51. doi:10.1074/jbc.275.12.8945. PMID 10722742.
• Sasaki A, Masuda Y, Iwai K, et al. (2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". J. Biol. Chem. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.