PLEK2

PLEK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X1G
Identifiers
Aliases	PLEK2
External IDs	MGI: 1351466 HomoloGene: 8447 GeneCards: PLEK2
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26499	27260
Ensembl	ENSG00000100558	ENSMUSG00000021118
UniProt	Q9NYT0	Q9WV52
RefSeq (mRNA)	NM_016445	NM_013738
RefSeq (protein)	NP_057529.1	NP_038766.1
Location (UCSC)	Chr 14: 67.39 – 67.41 Mb	Chr 12: 78.89 – 78.91 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Pleckstrin-2 is a protein that in humans is encoded by the PLEK2 gene.^[3][4][5] The PLEK2 gene is located on chromosome 14 in Homo sapiens and is flanked by TMEM229B to its right and ATP6V1D to its left.^[6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Lemmon, Mark A.; Ferguson, Kathryn M.; Abrams, Charles S. (2002). "Pleckstrin homology domains and the cytoskeleton". FEBS Letters. 513 (1): 71–76. doi:10.1016/S0014-5793(01)03243-4. PMID 11911883.
4. Hamaguchi N, Ihara S, Ohdaira T, Nagano H, Iwamatsu A, Tachikawa H, Fukui Y (Aug 2007). "Pleckstrin-2 selectively interacts with phosphatidylinositol 3-kinase lipid products and regulates actin organization and cell spreading". Biochem Biophys Res Commun. 361 (2): 270–5. doi:10.1016/j.bbrc.2007.06.132. PMID 17658464.
5. "Entrez Gene: PLEK2 pleckstrin 2".
6. "AceView: PLEK2 gene". AceView. National Library of Medicine. Retrieved 24 April 2011.

Further reading

• Bach TL, Kerr WT, Wang Y, et al. (2007). "PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization.". Blood. 109 (3): 1147–55. doi:10.1182/blood-2006-02-001339. PMC 1785144. PMID 17008542.
• Inazu T, Kuroiwa A, Matsuda Y, Miyamoto K (2005). "Cloning, expression and chromosomal assignment of human pleckstrin 2.". Mol. Biol. Rep. 32 (1): 35–40. doi:10.1007/s11033-004-4747-x. PMID 15865208.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Inazu T, Yamada K, Miyamoto K (1999). "Cloning and expression of pleckstrin 2, a novel member of the pleckstrin family.". Biochem. Biophys. Res. Commun. 265 (1): 87–93. doi:10.1006/bbrc.1999.1461. PMID 10548495.
• Hu MH, Bauman EM, Roll RL, et al. (1999). "Pleckstrin 2, a widely expressed paralog of pleckstrin involved in actin rearrangement.". J. Biol. Chem. 274 (31): 21515–8. doi:10.1074/jbc.274.31.21515. PMID 10419454.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.