PSMA8

PSMA8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4R3O, 4R67
Identifiers
Aliases	PSMA8, PSMA7L, proteasome subunit alpha 8
External IDs	MGI: 1920927 HomoloGene: 2086 GeneCards: PSMA8
Genetically Related Diseases
periodontitis[1]
Gene ontology Molecular function • endopeptidase activity • peptidase activity • threonine-type endopeptidase activity • hydrolase activity Cellular component • cytoplasm • cytosol • proteasome core complex, alpha-subunit complex • spermatoproteasome complex • proteasome complex • extracellular exosome • nucleus • proteasome core complex Biological process • regulation of cellular amino acid metabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • regulation of mRNA stability • ubiquitin-dependent protein catabolic process • positive regulation of canonical Wnt signaling pathway • protein polyubiquitination • stimulatory C-type lectin receptor signaling pathway • tumor necrosis factor-mediated signaling pathway • MAPK cascade • proteolysis • Fc-epsilon receptor signaling pathway • NIK/NF-kappaB signaling • anaphase-promoting complex-dependent catabolic process • proteolysis involved in cellular protein catabolic process • T cell receptor signaling pathway • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition • negative regulation of canonical Wnt signaling pathway • Wnt signaling pathway, planar cell polarity pathway • proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	143471	73677
Ensembl	ENSG00000154611	ENSMUSG00000036743
UniProt	Q8TAA3	Q9CWH6
RefSeq (mRNA)	NM_001025096 NM_001025097 NM_001308188 NM_144662	NM_001163609
RefSeq (protein)	NP_001020267.1 NP_001020268.1 NP_653263.2	NP_001157081.1
Location (UCSC)	Chr 18: 26.13 – 26.19 Mb	Chr 18: 14.71 – 14.76 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Proteasome subunit alpha 8 also known as proteasome subunit alpha type-7-like is a protein that in humans is encoded by the PSMA8 gene.^[4] Proteasome subunit alpha 8 is a component of the sperm specific proteasome.^[5]

References

1. "Diseases that are genetically associated with PSMA8 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. "Entrez Gene: PSMA8 proteasome subunit alpha 8".
5. de Mateo S, Castillo J, Estanyol JM, Ballescà JL, Oliva R (2011). "Proteomic characterization of the human sperm nucleus". Proteomics. 11 (13): 2714–26. doi:10.1002/pmic.201000799. PMID 21630459.