PTBP2

PTBP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CQ1, 2MJU, 4CQ1
Identifiers
Aliases	PTBP2, PTBLP, brPTB, nPTB, polypyrimidine tract binding protein 2
External IDs	MGI: 1860489 HomoloGene: 23162 GeneCards: PTBP2
Gene ontology Molecular function • mRNA binding • pre-mRNA binding • nucleotide binding • nucleic acid binding • poly(A) RNA binding • RNA binding Cellular component • growth cone • spliceosomal complex • neuronal cell body • nucleus Biological process • mRNA splice site selection • cerebellum development • mRNA processing • RNA splicing • spinal cord development • regulation of neural precursor cell proliferation • negative regulation of RNA splicing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	58155	56195
Ensembl	ENSG00000117569	ENSMUSG00000028134
UniProt	Q9UKA9	Q91Z31
RefSeq (mRNA)	NM_001300985 NM_001300986 NM_001300987 NM_001300988 NM_001300989 NM_001300990 NM_021190	NM_019550 NM_001310711
RefSeq (protein)	NP_001287914.1 NP_001287915.1 NP_001287916.1 NP_001287917.1 NP_001287918.1 NP_001287919.1 NP_067013.1	NP_001297640.1 NP_062423.1
Location (UCSC)	Chr 1: 96.72 – 96.82 Mb	Chr 3: 119.72 – 119.78 Mb
PubMed search	[1]	[2]
Wikidata

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Polypyrimidine tract binding protein 2, also known as PTBP2, is a protein which in humans is encoded by the PTBP2 gene.^[3][4]

Function

The protein encoded by this gene binds to the intronic cluster of RNA regulatory elements, downstream control sequence (DCS). It is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract-binding protein PTBP1 but it is expressed primarily in the brain.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Markovtsov V, Nikolic JM, Goldman JA, Turck CW, Chou MY, Black DL (October 2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. 20 (20): 7463–79. doi:10.1128/MCB.20.20.7463-7479.2000. PMC 86300. PMID 11003644.
4. "Entrez Gene: PTBP2 polypyrimidine tract binding protein 2".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.