Phosducin-like

PDCL
Identifiers
Aliases	PDCL, PhLP, Phosducin-like, phosducin like
External IDs	MGI: 1914716 HomoloGene: 38043 GeneCards: PDCL
Gene ontology Molecular function • protein complex binding • signal transducer activity, downstream of receptor • protein binding • queuine tRNA-ribosyltransferase activity Cellular component • cytoplasm • cytosol Biological process • queuosine biosynthetic process • heterotrimeric G-protein complex assembly • regulation of G-protein coupled receptor protein signaling pathway • negative regulation of protein refolding • signal transduction • visual perception • response to stimulus • protein folding Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5082	67466
Ensembl	ENSG00000136940	ENSMUSG00000009030
UniProt	Q13371	Q9DBX2
RefSeq (mRNA)	NM_005388	NM_026176
RefSeq (protein)	NP_005379.3	NP_080452.2
Location (UCSC)	Chr 9: 122.8 – 122.83 Mb	Chr 2: 37.35 – 37.36 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Phosducin-like protein is a protein that in humans is encoded by the PDCL gene.^[3][4]

Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Thibault C, Feng Wang J, Charnas R, Mirel D, Barhite S, Miles MF (May 1999). "Cloning and characterization of the rat and human phosducin-like protein genes: structure, expression and chromosomal localization". Biochim Biophys Acta. 1444 (3): 346–54. doi:10.1016/S0167-4781(99)00006-8. PMID 10095058.
4. "Entrez Gene: PDCL phosducin-like".

Further reading

• Miles MF, Barhite S, Sganga M, Elliott M (1993). "Phosducin-like protein: an ethanol-responsive potential modulator of guanine nucleotide-binding protein function.". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10831–5. doi:10.1073/pnas.90.22.10831. PMC 47872. PMID 8248177.
• Lazarov ME, Martin MM, Willardson BM, Elton TS (1999). "Human phosducin-like protein (hPhLP) messenger RNA stability is regulated by cis-acting instability elements present in the 3'-untranslated region.". Biochim. Biophys. Acta. 1446 (3): 253–64. doi:10.1016/S0167-4781(99)00098-6. PMID 10524200.
• Ruiz-Gómez A, Humrich J, Murga C, et al. (2000). "Phosphorylation of phosducin and phosducin-like protein by G protein-coupled receptor kinase 2.". J. Biol. Chem. 275 (38): 29724–30. doi:10.1074/jbc.M001864200. PMID 10884381.
• Lazarov ME, Martin MM, Willardson BM, Elton TS (2000). "Molecular cloning and characterization of the human phosducin-like protein (hPhLP) promoter.". Biochim. Biophys. Acta. 1492 (2-3): 460–4. doi:10.1016/S0167-4781(00)00137-8. PMID 10899582.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• McLaughlin JN, Thulin CD, Hart SJ, et al. (2002). "Regulatory interaction of phosducin-like protein with the cytosolic chaperonin complex.". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 7962–7. doi:10.1073/pnas.112075699. PMC 123003. PMID 12060742.
• Humrich J, Bermel C, Grubel T, et al. (2003). "Regulation of phosducin-like protein by casein kinase 2 and N-terminal splicing.". J. Biol. Chem. 278 (7): 4474–81. doi:10.1074/jbc.M206347200. PMID 12466282.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Carter MD, Southwick K, Lukov G, et al. (2005). "Identification of phosphorylation sites on phosducin-like protein by QTOF mass spectrometry.". J Biomol Tech. 15 (4): 257–64. PMC 2291704. PMID 15585822.
• Humrich J, Bermel C, Bünemann M, et al. (2005). "Phosducin-like protein regulates G-protein betagamma folding by interaction with tailless complex polypeptide-1alpha: dephosphorylation or splicing of PhLP turns the switch toward regulation of Gbetagamma folding.". J. Biol. Chem. 280 (20): 20042–50. doi:10.1074/jbc.M409233200. PMID 15745879.
• Lukov GL, Hu T, McLaughlin JN, et al. (2005). "Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly.". EMBO J. 24 (11): 1965–75. doi:10.1038/sj.emboj.7600673. PMC 1142607. PMID 15889144.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Lukov GL, Baker CM, Ludtke PJ, et al. (2006). "Mechanism of assembly of G protein betagamma subunits by protein kinase CK2-phosphorylated phosducin-like protein and the cytosolic chaperonin complex.". J. Biol. Chem. 281 (31): 22261–74. doi:10.1074/jbc.M601590200. PMID 16717095.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.