Polyethylenimine

Polyethylenimine
Names
IUPAC name
Poly(iminoethylene)
Other names
Polyaziridine, Poly[imino(1,2-ethanediyl)]
Identifiers
9002-98-6 YesY
ECHA InfoCard 100.123.818
Properties
(C2H5N)n, linear form
Molar mass 43.04 (repeat unit), mass of polymer variable
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
YesY verify (what is YesYN ?)
Infobox references

Polyethylenimine (PEI) or polyaziridine is a polymer with repeating unit composed of the amine group and two carbon aliphatic CH2CH2 spacer. Linear polyethyleneimines contain all secondary amines, in contrast to branched PEIs which contain primary, secondary and tertiary amino groups. Totally branched, dendrimeric forms were also reported.[1] PEI is produced on industrial scale and finds many applications usually derived from its polycationic character.[2]

Linear PEI fragment
Typical branched PEI fragment
PEI dendrimer generation 4

Properties

The linear PEIs are solids at room temperature while branched PEIs are liquids at all molecular weights. Linear polyethyleneimines are soluble in hot water, at low pH, in methanol, ethanol, or chloroform. They are insoluble in cold water, benzene, ethyl ether, and acetone. They have a melting point of 73-75°C. They can be stored at room temperature.

Synthesis

Branched PEI can be synthesized by the ring opening polymerization of aziridine.[3] Depending on the reaction conditions different degree of branching can be achieved. Linear PEI is available by post-modification of other polymers like poly(2-oxazolines) [4] or N-substituted polyaziridines.[5] Linear PEI was synthesised by the hydrolysis of poly(2-ethyl-2-oxazoline)[6] and sold as jetPEI.[7] The current generation in-vivo-jetPEI uses bespoke poly(2-ethyl-2-oxazoline) polymers as precursors.[8]

Applications

Polyethyleneimine finds many applications in products like: detergents, adhesives, water treatment agents and cosmetics.[9] Thanks to ability to modify the surface of cellulose fibres, PEI is employed as a wet-strength agent in the paper-making process.[10] It is also used as flocculating agent with silica sols and as a chelating agent with the ability to complex metal ions such as zinc and zirconium.[11] There are also other highly specialized PEI applications:

Attachment promoter

Polyethyleneimines are used in the cell culture of weakly anchoring cells to increase attachment. PEI is a cationic polymer; the negatively charged outer surfaces of cells are attracted to dishes coated in PEI, facilitating stronger attachments between the cells and the plate. However, polyethylenimine expresses some toxicity if excess is left in solution.[12]

Transfection reagent

Poly(ethylenimine) was the second polymeric transfection agent discovered,[13] after poly-l-lysine. PEI condenses DNA into positively charged particles, which bind to anionic cell surface residues and are brought into the cell via endocytosis. Once inside the cell protonation of the amines results in an influx of counter-ions and a lowering of the osmotic potential. Osmotic swelling results and bursts the vesicle releasing the polymer-DNA complex (polyplex) into the cytoplasm. If the polyplex unpacks then the DNA is free to diffuse to the nucleus.[14][15] PEI is extremely cytotoxic,[16] by two different mechanisms,[17] the disruption of the cell membrane leading to necrotic cell death (immediate) and disruption of the mitochondrial membrane after internalisation leading to apoptosis (delayed).

CO2 capture

Both linear and branched polyethylenimine have been used for CO2 capture, frequently impregnated over porous materials. First use of PEI polymer in CO2 capture was devoted to improve the CO2 removal in space craft applications, impregnated over a polymeric matrix.[18] After that, the support was changed to MCM-41, an hexagonal mesostructured silica, and large amounts of PEI were retained in the so-called "molecular basket".[19] MCM-41-PEI adsorbent materials led to higher CO2 adsorption capacities than bulk PEI or MCM-41 material individually considered. The authors claim that, in this case, a synergic effect takes place due to the high PEI dispersion inside the pore structure of the material. As a result of this improvement, further works were developed to study more in depth the behaviour of these materials. Exhaustive works have been focused on the CO2 adsorption capacity as well as the CO2/O2 and CO2/N2 adsorption selectivity of several MCM-41-PEI materials with PEI polymers.[20][21] Also, PEI impregnation has been tested over different supports such as a glass fiber matrix [22] and monoliths.[23] However, for an appropriate performance under real conditions in post-combustion capture (mild temperatures between 45-75°C and the presence of moisture) it is necessary to use thermally and hydrothermally stable silica materials, such as SBA-15,[24] which also presents an hexagonal mesostructure. Moisture and real world conditions have also been tested when using PEI-impregnated materials to adsorb CO2 from the air.[25] A detailed comparison among PEI and other amino-containing molecules showed an excellence performance of PEI-containing samples with cycles. Also, only a slight decrease was registered in their CO2 uptake when increasing the temperature from 25 to 100°C, demonstrating a high contribution of chemisorption to the adsorption capacity of these solids. For the same reason, the adsorption capacity under diluted CO2 was up to 90% of the value under pure CO2 and also, a high unwanted selectivity towards SO2 was observed.[26] Lately, many efforts have been made in order to improve PEI diffusion within the porous structure of the support used. A better dispersion of PEI and a higher CO2 efficiency (CO2/NH molar ratio) were achieved by impregnating a template-occluded PE-MCM-41 material rather than perfect cylindrical pores of a calcined material,[27] following a previously described route.[28] The combined use of organosilanes such as aminopropyl-trimethoxysilane, AP, and PEI has also been studied. The first approach used a combination of them to impregnate porous supports, achieving faster CO2-adsorption kinetics and higher stability during reutilization cycles, but no higher efficiencies.[29] A novel method is the so-called "double-functionalization". It is based on the impregnation of materials previously functionalized by grafting (covalent bonding of organosilanes). Amino groups incorporated by both paths have shown synergic effects, achieving high CO2 uptakes up to 235 mg CO2/g (5.34 mmol CO2/g).[30] CO2 adsorption kinetics were also studied for these materials, showing similar adsorption rates than impregnated solids.[31] This is an interesting finding, taking into account the smaller pore volume available in double-functionalized materials. Thus, it can be also concluded that their higher CO2 uptake and efficiency compared to impregnated solids can be ascribed to a synergic effect of the amino groups incorporated by two methods (grafting and impregnation) rather than to a faster adsorption kinetics.

Low work function modifier for electronics

Poly(ethylenimine) and Poly(ethylenimine) ethoxylated (PEIE) have been shown as effective low-work function modifiers for organic electronics by Zhou and Kippelen et al.[32] It could universally reduce the work function of metals, metal oxides, conducting polymers and graphene, and so on. It is very important that low-work function solution-processed conducting polymer could be produced by the PEI or PEIE modification. Based on this discovery, the polymers have been widely used for organic solar cells, organic light-emitting diodes, organic field-effect transistors, perovskite solar cells, perovksite light-emitting diodes, quantum-dot solar cells and light-emitting diodes etc.

References

  1. ↑ Yemuland, Omprakash; Imae, Toyoko (2008). "Synthesis and characterization of poly(ethyleneimine) dendrimers". Colloid & Polymer Science. 286 (6–7): 747–752. doi:10.1007/s00396-007-1830-6.
  2. ↑ Davidson, Robert L.; Sittig, Marshall (1968). Water-soluble resins. Reinhold Book Corp. ISBN 0278916139.
  3. ↑ Zhuk, D. S., Gembitskii, P. A., and Kargin V. A. Russian Chemical Reviews; Vol 34:7.1965
  4. ↑ Tanaka, Ryuichi; Ueoka, Isao; Takaki, Yasuhiro; Kataoka, Kazuya; Saito, Shogo (1983). "High molecular weight linear polyethylenimine and poly(N-methylethylenimine)". Macromolecules. 16 (6): 849–853. doi:10.1021/ma00240a003.
  5. ↑ Weyts, Katrien F.; Goethals, Eric J. (1988). "New synthesis of linear polyethyleneimine". Polymer Bulletin. 19 (1): 13–19. doi:10.1007/bf00255018.
  6. ↑ Brissault, B.; et al. (2003). "Synthesis of Linear Polyethylenimine Derivatives for DNA Transfection". Bioconjugate Chemistry. 14: 581–587. doi:10.1021/bc0200529.
  7. ↑ http://www.polyplus-transfection.com/transfection-reagents/high-throughput-screening-jetpei/
  8. ↑ http://www.wipo.int/pctdb/en/wo.jsp?WO=2009016507&IA=IB2008002339&DISPLAY=DOCS
  9. ↑ "Poly(ethyleneimine) solution". Sigma-Aldrich. Retrieved 24 December 2012.
  10. ↑ Wågberg, Lars (2000). "Polyelectrolyte adsorption onto cellulose fibres – a review". Nordic Pulp & Paper Research Journal. 15 (5): 586–597. doi:10.3183/NPPRJ-2000-15-05-p586-597.
  11. ↑ Madkour, Tarek M. (1999). Polymer Data Handbook. Oxford University Press, Inc. p. 490. ISBN 978-0195107890.
  12. ↑ Vancha AR; et al. (2004). "Use of polyethyleneimine polymer in cell culture as attachment factor and lipofection enhancer". BMC Biotechnology. 4: 23. doi:10.1186/1472-6750-4-23. PMC 526208Freely accessible. PMID 15485583.
  13. ↑ Boussif, O.; et al. (1995). "A Versatile Vector for Gene and Oligonucleotide Transfer into Cells in Culture and in vivo: Polyethylenimine". Proceedings of the National Academy of Sciences. 92: 7297–7301. doi:10.1073/pnas.92.16.7297.
  14. ↑ Rudolph, C; Lausier, J; Naundorf, S; Müller, RH; Rosenecker, J (2000). "In vivo gene delivery to the lung using polyethylenimine and fractured polyamidoamine dendrimers". Journal of Gene Medicine. 2 (4): 269–78. doi:10.1002/1521-2254(200007/08)2:4<269::AID-JGM112>3.0.CO;2-F. PMID 10953918.
  15. ↑ Akinc, A; Thomas, M; Klibanov, AM; Langer, R (2004). "Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis". Journal of Gene Medicine. 7 (5): 657–663. doi:10.1002/jgm.696. PMID 15543529.
  16. ↑ Hunter, A. C. (2006). "Molecular hurdles in polyfectin design and mechanistic background to polycation induced cytotoxicity". Advanced Drug Delivery Reviews. 58: 1523–1531. doi:10.1016/j.addr.2006.09.008.
  17. ↑ Moghimi, S. M.; et al. (2005). "A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy". Molecular Therapy. 11: 990–995. doi:10.1016/j.ymthe.2005.02.010.
  18. ↑ Satyapal, S.; Filburn, T.; Trela, J.; Strange, J. (2001). Energy & Fuels. 15: 250–255. doi:10.1021/ef0002391. Missing or empty |title= (help)
  19. ↑ Xu, X.; Song, C.; Andrésen, J. M.; Miller, B. G.; Scaroni, A. W. (2002). Energy & Fuels. 16: 1463–1469. doi:10.1021/ef020058u. Missing or empty |title= (help)
  20. ↑ X. Xu, C. Song, R. Wincek J. M. Andrésen, B. G. Miller, A. W. Scaroni, Fuel Chem. Div. Prepr. 2003; 48 162-163
  21. ↑ X. Xu, C. Song, B. G. Miller, A. W. Scaroni, Ind. Eng. Chem. Res. 2005; 44 8113-8119
  22. ↑ Li, P.; Ge, B.; Zhang, S.; Chen, S.; Zhang, Q.; Zhao, Y. (2008). Langmuir. 24: 6567–6574. doi:10.1021/la800791s. Missing or empty |title= (help)
  23. ↑ C. Chen, S. T. Yang, W. S. Ahn, R. Ryoo, "Title" Chem. Commun. (2009) 3627-3629
  24. ↑ Sanz, R.; Calleja, G.; Arencibia, A.; Sanz-Pérez, E. S. (2010). "Title" Appl. Surf". Sci. 256: 5323–5328.
  25. ↑ Goeppert, A.; Czaun, M.; May, R. B.; Prakash, G. K. Surya; Olah, G. A.; Narayanan, S. R. (2011). JACS. 133: 20164. Missing or empty |title= (help)
  26. ↑ Sanz-Pérez, E.S.; Olivares-Marín, M.; Arencibia, A.; Sanz, R.; Calleja, G.; Maroto-Valer, M.M. (2013). Int. J. Greenh. Gas Control. 17: 366. Missing or empty |title= (help)
  27. ↑ Heydari-Gorji, A.; Belmabkhout, Y.; Sayari, A. (2011). Langmuir. 27: 12411. doi:10.1021/la202972t. Missing or empty |title= (help)
  28. ↑ Yue, M.B.; Sun, L.B.; Cao, Y.; Wang, Y.; Wang, Z.J.; Zhu, J.H. (2008). Chem. Eur. J. 14: 3442. doi:10.1002/chem.200701467. Missing or empty |title= (help)
  29. ↑ Choi, S.; Gray, M. L.; Jones, C.W. (2011). [onlinelibrary.wiley.com/doi/10.1002/cssc.201000355/abstract "Amine-tethered solid absorbents coupling high adsorption capacity and regenerability for CO2 capture from ambient air"] Check |url= value (help). Chem. Sus. Chem. 4: 628.
  30. ↑ Sanz, R.; Calleja, G.; Arencibia, A.; Sanz-Pérez, E.S. (2013). J. Mater. Chem. A. 6: 1956. Missing or empty |title= (help)
  31. ↑ Sanz, R.; Calleja, G.; Arencibia, A.; Sanz-Pérez, E.S. (2013). Energ. Fuel. 27: 7637. Missing or empty |title= (help)
  32. ↑ Zhou, Y. H.; Fuentes-Hernandez, C.; Shim, J.; Meyer, J.; Giordano, A. J.; Li, H.; Winget, P.; Papadopoulos, T.; Cheun, H.; Kim, J.; Fenoll, M.; Dindar, A.; Haske, W.; Najafabadi, E.; Khan, T. M.; Sojoudi, H.; Barlow, S.; Graham, S.; Bredas, J. L.; Marder, S. R.; Kahn, A.; Kippelen, B. Science 2012, 336, 327. doi: 10.1126/science.1218829
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