RAB5C

RAB5C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4KYI
Identifiers
Aliases	RAB5C, L1880, RAB5CL, RAB5L, RABL, member RAS oncogene family
External IDs	MGI: 105306 HomoloGene: 55533 GeneCards: RAB5C
Gene ontology Molecular function • nucleotide binding • GTP binding • protein binding • GTPase activity • GDP binding Cellular component • melanosome • lysosomal membrane • endosome • lipid particle • plasma membrane • endocytic vesicle • early endosome • early endosome membrane • extracellular exosome • intracellular membrane-bounded organelle • membrane • intracellular Biological process • protein transport • regulation of endocytosis • small GTPase mediated signal transduction • plasma membrane to endosome transport • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5878	19345
Ensembl	ENSG00000108774	ENSMUSG00000019173
UniProt	P51148	P35278
RefSeq (mRNA)	NM_001252039 NM_004583 NM_201434	NM_024456 NM_001305003
RefSeq (protein)	NP_001238968.1 NP_004574.2 NP_958842.1	NP_077776.2
Location (UCSC)	Chr 17: 42.12 – 42.16 Mb	Chr 11: 100.72 – 100.74 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Ras-related protein Rab-5C is a protein that in humans is encoded by the RAB5C gene.^[3][4] RAB5C belongs to the Ras-related protein family.

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Han HJ, Sudo K, Inazawa J, Nakamura Y (Jul 1996). "Isolation and mapping of a human gene (RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene". Cytogenet Cell Genet. 73 (1-2): 137–9. doi:10.1159/000134325. PMID 8646882.
4. "Entrez Gene: RAB5C RAB5C, member RAS oncogene family".

Further reading

• Albertsen HM, Smith SA, Mazoyer S, et al. (1994). "A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21.". Nat. Genet. 7 (4): 472–9. doi:10.1038/ng0894-472. PMID 7951316.
• Alvarez-Dominguez C, Stahl PD (1999). "Interferon-gamma selectively induces Rab5a synthesis and processing in mononuclear cells.". J. Biol. Chem. 273 (51): 33901–4. doi:10.1074/jbc.273.51.33901. PMID 9852039.
• Bucci C, Chiariello M, Lattero D, et al. (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1).". Biochem. Biophys. Res. Commun. 258 (3): 657–62. doi:10.1006/bbrc.1999.0651. PMID 10329441.
• Clemens DL, Lee BY, Horwitz MA (2000). "Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate.". Infect. Immun. 68 (5): 2671–84. doi:10.1128/IAI.68.5.2671-2684.2000. PMC 97474. PMID 10768959.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Merithew E, Stone C, Eathiraj S, Lambright DG (2003). "Determinants of Rab5 interaction with the N terminus of early endosome antigen 1.". J. Biol. Chem. 278 (10): 8494–500. doi:10.1074/jbc.M211514200. PMID 12493736.
• Kajiho H, Saito K, Tsujita K, et al. (2004). "RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway.". J. Cell. Sci. 116 (Pt 20): 4159–68. doi:10.1242/jcs.00718. PMID 12972505.
• Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.