RAPH1

RAPH1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4GMV, 4GN1
Identifiers
Aliases	RAPH1, ALS2CR18, ALS2CR9, LPD, PREL-2, PREL2, RMO1, RalGDS/AF-6, Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
External IDs	MGI: 1924550 HomoloGene: 71030 GeneCards: RAPH1
Gene ontology Molecular function • protein binding Cellular component • cytoplasm • filopodium • plasma membrane • cell projection • cytoskeleton • cell leading edge • membrane • lamellipodium Biological process • signal transduction • axon extension Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	65059	77300
Ensembl	ENSG00000173166	ENSMUSG00000026014
UniProt	Q70E73	n/a
RefSeq (mRNA)	NM_025252 NM_203365 NM_213589	NM_001045513
RefSeq (protein)	NP_976241.1 NP_998754.1	n/a
Location (UCSC)	Chr 2: 203.39 – 203.54 Mb	Chr 1: 60.48 – 60.57 Mb
PubMed search	[1]	[2]
Wikidata

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Ras-associated and pleckstrin homology domains-containing protein 1 is a protein that in humans is encoded by the RAPH1 gene.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1".

Further reading

• Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
• Hadano S, Hand CK, Osuga H, et al. (2001). "A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.". Nat. Genet. 29 (2): 166–73. doi:10.1038/ng1001-166. PMID 11586298.
• Salazar MA, Kwiatkowski AV, Pellegrini L, et al. (2004). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton.". J. Biol. Chem. 278 (49): 49031–43. doi:10.1074/jbc.M308104200. PMID 14506234.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Krause M, Leslie JD, Stewart M, et al. (2004). "Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics.". Dev. Cell. 7 (4): 571–83. doi:10.1016/j.devcel.2004.07.024. PMID 15469845.
• Dahl E, Sadr-Nabavi A, Klopocki E, et al. (2005). "Systematic identification and molecular characterization of genes differentially expressed in breast and ovarian cancer.". J. Pathol. 205 (1): 21–8. doi:10.1002/path.1687. PMID 15586368.
• Eppert K, Wunder JS, Aneliunas V, et al. (2005). "Altered expression and deletion of RMO1 in osteosarcoma.". Int. J. Cancer. 114 (5): 738–46. doi:10.1002/ijc.20786. PMID 15609301.
• Jenzora A, Behrendt B, Small JV, et al. (2005). "PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins.". FEBS Lett. 579 (2): 455–63. doi:10.1016/j.febslet.2004.10.110. PMID 15642358.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.