RASGRP2

RASGRP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MA2
Identifiers
Aliases	RASGRP2, CALDAG-GEFI, CDC25L, RAS guanyl releasing protein 2
External IDs	MGI: 1333849 HomoloGene: 4250 GeneCards: RASGRP2
Gene ontology Molecular function • calcium ion binding • metal ion binding • diacylglycerol binding • lipid binding • guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • cytosol • cell projection • membrane • plasma membrane • synapse • ruffle membrane • cell junction • neuron projection Biological process • cellular response to calcium ion • intracellular signal transduction • small GTPase mediated signal transduction • positive regulation of GTPase activity • regulation of cell growth • Ras protein signal transduction • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10235	19395
Ensembl	ENSG00000068831	n/a
UniProt	Q7LDG7	Q9QUG9
RefSeq (mRNA)	NM_001098670 NM_001098671 NM_005825 NM_153819 NM_001318398	NM_011242
RefSeq (protein)	NP_001092140.1 NP_001092141.1 NP_722541.1 NP_001305327.1	NP_035372.2
Location (UCSC)	Chr 11: 64.73 – 64.75 Mb	Chr 19: 6.4 – 6.42 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

RAS guanyl-releasing protein 2 is a protein that in humans is encoded by the RASGRP2 gene.^[3][4]

The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Two alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been reported.^[4]

Clinical significance

Mutations in RASGRP2 are associated with severe bleeding .^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Kawasaki H, Springett GM, Toki S, Canales JJ, Harlan P, Blumenstiel JP, Chen EJ, Bany IA, Mochizuki N, Ashbacher A, Matsuda M, Housman DE, Graybiel AM (Nov 1998). "A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia". Proc Natl Acad Sci U S A. 95 (22): 13278–83. doi:10.1073/pnas.95.22.13278. PMC 23782. PMID 9789079.
4. "Entrez Gene: RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)".
5. Canault, M; Ghalloussi, D; Grosdidier, C; Guinier, M; Perret, C; Chelghoum, N; Germain, M; Raslova, H; Peiretti, F; Morange, P. E.; Saut, N; Pillois, X; Nurden, A. T.; Cambien, F; Pierres, A; Van Den Berg, T. K.; Kuijpers, T. W.; Alessi, M. C.; Tregouet, D. A. (2014). "Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding". Journal of Experimental Medicine. 211: 1349–62. doi:10.1084/jem.20130477. PMID 24958846.

Further reading

• Kedra D, Seroussi E, Fransson I, et al. (1997). "The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13.". Hum. Genet. 100 (5-6): 611–9. doi:10.1007/s004390050562. PMID 9341881.
• Clyde-Smith J, Silins G, Gartside M, et al. (2000). "Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor.". J. Biol. Chem. 275 (41): 32260–7. doi:10.1074/jbc.M006087200. PMID 10918068.
• Guo FF, Kumahara E, Saffen D (2001). "A CalDAG-GEFI/Rap1/B-Raf cassette couples M(1) muscarinic acetylcholine receptors to the activation of ERK1/2.". J. Biol. Chem. 276 (27): 25568–81. doi:10.1074/jbc.M101277200. PMID 11292831.
• Toki S, Kawasaki H, Tashiro N, et al. (2001). "Guanine nucleotide exchange factors CalDAG-GEFI and CalDAG-GEFII are colocalized in striatal projection neurons.". J. Comp. Neurol. 437 (4): 398–407. doi:10.1002/cne.1291. PMID 11503142.
• Eto K, Murphy R, Kerrigan SW, et al. (2002). "Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 12819–24. doi:10.1073/pnas.202380099. PMC 130543. PMID 12239348.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Katagiri K, Shimonaka M, Kinashi T (2004). "Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1.". J. Biol. Chem. 279 (12): 11875–81. doi:10.1074/jbc.M310717200. PMID 14702343.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

• RASGRP2 human gene location in the UCSC Genome Browser.
• RASGRP2 human gene details in the UCSC Genome Browser.