RBM39

RBM39
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases RBM39, CAPER, CAPERalpha, FSAP59, HCC1, RNPC2, RNA binding motif protein 39
External IDs MGI: 2157953 HomoloGene: 136465 GeneCards: RBM39
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

9584

170791

Ensembl

ENSG00000131051

ENSMUSG00000027620

UniProt

Q14498
Q5QP23

Q8VH51

RefSeq (mRNA)

NM_001291114
NM_001291115
NM_133242

RefSeq (protein)

NP_001229528.1
NP_001229529.1
NP_004893.1
NP_909122.1

NP_001278043.1
NP_001278044.1
NP_573505.2

Location (UCSC) Chr 20: 35.7 – 35.74 Mb Chr 2: 156.15 – 156.18 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

RNA-binding protein 39 is a protein that in humans is encoded by the RBM39 gene.[3][4]

Function

The protein encoded by this gene is an RNA binding protein and possible splicing factor. The encoded protein is found in the nucleus, where it colocalizes with core spliceosomal proteins. Studies of a mouse protein with high sequence similarity to this protein suggest that this protein may act as a transcriptional coactivator for JUN/AP-1 and estrogen receptors. Multiple transcript variants encoding different isoforms have been observed for this gene.[4]

Interactions

RBM39 has been shown to interact with Estrogen receptor alpha,[5] Estrogen receptor beta[5] and C-jun.[5]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Imai H, Chan EK, Kiyosawa K, Fu XD, Tan EM (Dec 1993). "Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma". J Clin Invest. 92 (5): 2419–26. doi:10.1172/JCI116848. PMC 288425Freely accessible. PMID 8227358.
  4. 1 2 "Entrez Gene: RBM39 RNA binding motif protein 39".
  5. 1 2 3 Jung DJ, Na SY, Na DS, Lee JW (Jan 2002). "Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors". J. Biol. Chem. 277 (2): 1229–34. doi:10.1074/jbc.M110417200. PMID 11704680.

Further reading

  • Jung DJ, Na SY, Na DS, Lee JW (2002). "Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors". J. Biol. Chem. 277 (2): 1229–34. doi:10.1074/jbc.M110417200. PMID 11704680. 
  • Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819. 
  • Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. 
  • Dowhan DH, Hong EP, Auboeuf D, Dennis AP, Wilson MM, Berget SM, O'Malley BW (2005). "Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta". Mol. Cell. 17 (3): 429–39. doi:10.1016/j.molcel.2004.12.025. PMID 15694343. 
  • Sun NN, Fastje CD, Wong SS, Sheppard PR, Macdonald SJ, Ridenour G, Hyde JD, Witten ML (2005). "Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line". Toxicology and industrial health. 19 (7–10): 157–63. doi:10.1191/0748233703th185oa. PMID 15747776. 
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 


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