RNF38

RNF38
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X4J, 4V3K, 4V3L
Identifiers
Aliases	RNF38
External IDs	MGI: 1920719 HomoloGene: 32550 GeneCards: RNF38
Gene ontology Molecular function • zinc ion binding • ligase activity • metal ion binding • ubiquitin-protein transferase activity • ubiquitin protein ligase activity Cellular component • sperm flagellum • nucleus • cytoplasm • nucleoplasm Biological process • male gonad development • protein ubiquitination • regulation of transcription, DNA-templated • proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	152006	73469
Ensembl	ENSG00000137075	ENSMUSG00000035696
UniProt	Q9H0F5	Q8BI21
RefSeq (mRNA)	NM_022781 NM_194328 NM_194329 NM_194330 NM_194331 NM_194332	NM_001038993 NM_175201
RefSeq (protein)	NP_073618.3 NP_919309.1 NP_919310.1 NP_919311.1 NP_919313.1	NP_780410.2
Location (UCSC)	Chr 9: 36.34 – 36.49 Mb	Chr 4: 44.13 – 44.23 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

RING finger protein 38 is a protein that in humans is encoded by the RNF38 gene.^[3]

This gene encodes a protein with a coiled-coil motif and a RING-H2 motif (C3H2C2) at its carboxy-terminus. The RING motif is a zinc-binding domain found in a large set of proteins playing roles in diverse cellular processes including oncogenesis, development, signal transduction, and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[3]

See also

• RING finger domain

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: RNF38 ring finger protein 38".

Further reading

• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–D418. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–374. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Eisenberg I, Hochner H, Levi T, et al. (2002). "Cloning and characterization of a novel human gene RNF38 encoding a conserved putative protein with a RING finger domain". Biochem. Biophys. Res. Commun. 294 (5): 1169–1176. doi:10.1016/S0006-291X(02)00584-3. PMID 12074600.
• Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–15094. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

External links

• RNF38 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)