40S ribosomal protein S12

RPS12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4V6X, 5A2Q, 5AJ0, 4KZY, 4D61, 5FLX, 4KZX, 4D5L, 4UJD, 4KZZ, 4UJE, 4UJC
Identifiers
Aliases	RPS12, S12, ribosomal protein S12
External IDs	MGI: 98105 HomoloGene: 110750 GeneCards: RPS12
Gene ontology Molecular function • poly(A) RNA binding • structural constituent of ribosome Cellular component • ribosome • cytoplasm • cytosol • membrane • intracellular • intracellular ribonucleoprotein complex • cytosolic small ribosomal subunit • nucleoplasm Biological process • SRP-dependent cotranslational protein targeting to membrane • viral transcription • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • translational initiation • translation • rRNA processing Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6206	20042
Ensembl	ENSG00000112306	ENSMUSG00000061983
UniProt	P25398	P63323
RefSeq (mRNA)	NM_001016	NM_011295
RefSeq (protein)	NP_001007.2	n/a
Location (UCSC)	Chr 6: 132.81 – 132.82 Mb	Chr 10: 23.79 – 23.79 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

40S ribosomal protein S12 is a protein that in humans is encoded by the RPS12 gene.^[3][4][5]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Herault Y, Michel D, Chatelain G, Brun G (Aug 1991). "cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17". Nucleic Acids Res. 19 (14): 4001. doi:10.1093/nar/19.14.4001. PMC 328500. PMID 1861993.
4. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
5. "Entrez Gene: RPS12 ribosomal protein S12".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Pogue-Geile K, Geiser JR, Shu M, et al. (1991). "Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein". Mol. Cell. Biol. 11 (8): 3842–9. PMC 361167. PMID 1712897.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Cheng Q, Lau WM, Chew SH, et al. (2002). "Identification of molecular markers for the early detection of human squamous cell carcinoma of the uterine cervix". Br. J. Cancer. 86 (2): 274–81. doi:10.1038/sj.bjc.6600038. PMC 2375172. PMID 11870519.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.