40S ribosomal protein S29

RPS29
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 4KZY, 4D61, 5FLX, 4KZX, 4D5L, 4V5Z, 4UJD, 4KZZ, 4UJE, 4UJC
Identifiers
Aliases	RPS29, DBA13, S29, ribosomal protein S29
External IDs	MGI: 107681 HomoloGene: 83197 GeneCards: RPS29
Gene ontology Molecular function • structural constituent of ribosome • zinc ion binding • metal ion binding Cellular component • cytoplasm • cytosol • ribosome • focal adhesion • intracellular ribonucleoprotein complex • intracellular • cytosolic small ribosomal subunit • small ribosomal subunit • extracellular exosome • nucleoplasm Biological process • viral transcription • SRP-dependent cotranslational protein targeting to membrane • translational initiation • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • translation • rRNA processing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6235	20090
Ensembl	ENSG00000213741	ENSMUSG00000034892
UniProt	P62273	P62274
RefSeq (mRNA)	NM_001032 NM_001030001	NM_009093
RefSeq (protein)	NP_001023.1 NP_001025172.1	NP_033119.1
Location (UCSC)	Chr 14: 49.57 – 49.6 Mb	Chr 12: 69.16 – 69.16 Mb
PubMed search	[1]	[2]
Wikidata

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40S ribosomal protein S29 is a protein that in humans is encoded by the RPS29 gene.^[3][4][5]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit and a member of the S14P family of ribosomal proteins. The protein, which contains a C2-C2 zinc finger-like domain that can bind to zinc, can enhance the tumor suppressor activity of Ras-related protein 1A (KREV1). It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[5]

Clinical aspect

Mutations in RPS29 cause Diamond-Blackfan anemia .^[6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Kondoh N, Noda M, Fisher RJ, Schweinfest CW, Papas TS, Kondoh A, Samuel KP, Oikawa T (Oct 1996). "The S29 ribosomal protein increases tumor suppressor activity of K rev-1 gene on v-K ras-transformed NIH3T3 cells". Biochim Biophys Acta. 1313 (1): 41–6. doi:10.1016/0167-4889(96)00052-3. PMID 8781548.
4. Frigerio JM, Dagorn JC, Iovanna JL (Jul 1995). "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs". Biochim Biophys Acta. 1262 (1): 64–8. doi:10.1016/0167-4781(95)00045-i. PMID 7772601.
5. "Entrez Gene: RPS29 ribosomal protein S29".
6. Mirabello, L; MacAri, E. R.; Jessop, L; Ellis, S. R.; Myers, T; Giri, N; Taylor, A. M.; McGrath, K. E.; Humphries, J. M.; Ballew, B. J.; Yeager, M; Boland, J. F.; He, J; Hicks, B. D.; Burdett, L; Alter, B. P.; Zon, L; Savage, S. A. (2014). "Whole-exome sequencing and functional studies identify RPS29 as a novel gene mutated in multi-case Diamond-Blackfan anemia families". Blood. 124 (1): 24–32. doi:10.1182/blood-2013-11-540278. PMID 24829207.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11-12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
• Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes.". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
• Coppock D, Kopman C, Gudas J, Cina-Poppe DA (2000). "Regulation of the quiescence-induced genes: quiescin Q6, decorin, and ribosomal protein S29.". Biochem. Biophys. Res. Commun. 269 (2): 604–10. doi:10.1006/bbrc.2000.2324. PMID 10708601.
• Bortoluzzi S, d'Alessi F, Romualdi C, Danieli GA (2002). "Differential expression of genes coding for ribosomal proteins in different human tissues.". Bioinformatics. 17 (12): 1152–7. doi:10.1093/bioinformatics/17.12.1152. PMID 11751223.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhou ZD, Bao L, Liu DG, et al. (2003). "Low content of protein S29 in ribosomes of human lung cancer cell line a549: detected by two-dimensional electrophoresis.". Protein Pept. Lett. 10 (1): 91–7. doi:10.2174/0929866033408273. PMID 12625830.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes.". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.