40S ribosomal protein S3

RPS3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WH9, 4UG0, 4V6X, 5A2Q, 5AJ0, 3J7P, 4UJE, 4D5L, 3J7R, 4UJD, 4V5Z, 5FLX, 4D61, 4UJC
Identifiers
Aliases	RPS3, S3, ribosomal protein S3
External IDs	MGI: 1350917 HomoloGene: 779 GeneCards: RPS3
Gene ontology Molecular function • SUMO binding • tubulin binding • DNA N-glycosylase activity • small ribosomal subunit rRNA binding • iron-sulfur cluster binding • transcription factor binding • oxidized purine DNA binding • Hsp70 protein binding • lyase activity • enzyme binding • mRNA binding • structural constituent of ribosome • damaged DNA binding • ubiquitin-like protein conjugating enzyme binding • protein binding • DNA-(apurinic or apyrimidinic site) lyase activity • oxidized pyrimidine DNA binding • endodeoxyribonuclease activity • protein kinase binding • supercoiled DNA binding • DNA binding • Hsp90 protein binding • microtubule binding • protein kinase A binding • RNA binding • poly(A) RNA binding • kinase binding Cellular component • cytoplasm • cytosol • polysome • membrane • focal adhesion • ruffle membrane • mitochondrion • cytoskeleton • nucleus • ribosome • nucleolus • extracellular exosome • plasma membrane • spindle • mitochondrial matrix • small ribosomal subunit • mitotic spindle • intracellular ribonucleoprotein complex • mitochondrial inner membrane • cytosolic small ribosomal subunit • nucleoplasm • extracellular matrix Biological process • chromosome segregation • positive regulation of endodeoxyribonuclease activity • cellular response to DNA damage stimulus • positive regulation of microtubule polymerization • cell cycle • DNA damage response, detection of DNA damage • apoptotic process • negative regulation of translation • regulation of transcription, DNA-templated • viral transcription • response to TNF agonist • positive regulation of apoptotic signaling pathway • response to oxidative stress • transcription, DNA-templated • SRP-dependent cotranslational protein targeting to membrane • positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis • positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage • positive regulation of DNA N-glycosylase activity • positive regulation of JUN kinase activity • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • mitotic nuclear division • negative regulation of DNA repair • positive regulation of DNA repair • positive regulation of NIK/NF-kappaB signaling • cell division • spindle assembly • negative regulation of protein ubiquitination • positive regulation of gene expression • translational initiation • regulation of translation • cellular response to hydrogen peroxide • translation • positive regulation of base-excision repair • DNA repair • regulation of apoptotic process • rRNA processing Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6188	27050
Ensembl	ENSG00000149273	ENSMUSG00000030744
UniProt	P23396	P62908
RefSeq (mRNA)	NM_001260507 NM_001005 NM_001256802 NM_001260506	NM_012052
RefSeq (protein)	NP_000996.2 NP_001243731.1 NP_001247435.1 NP_001247436.1	NP_036182.1
Location (UCSC)	Chr 11: 75.4 – 75.42 Mb	Chr 7: 99.48 – 99.48 Mb
PubMed search	[1]	[2]
Wikidata

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40S ribosomal protein S3 is a protein that in humans is encoded by the RPS3 gene.^[3][4][5]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Pogue-Geile K, Geiser JR, Shu M, Miller C, Wool IG, Meisler AI, Pipas JM (Aug 1991). "Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein". Mol. Cell. Biol. 11 (8): 3842–9. PMC 361167. PMID 1712897.
4. Polakiewicz RD, Munroe DJ, Sait SN, Tycowski KT, Nowak NJ, Shows TB, Housman DE, Page DC (Jul 1995). "Mapping of ribosomal protein S3 and internally nested snoRNA U15A gene to human chromosome 11q13.3-q13.5". Genomics. 25 (2): 577–80. doi:10.1016/0888-7543(95)80063-R. PMID 7789996.
5. "Entrez Gene: RPS3 ribosomal protein S3".

Further reading

• Bommer UA, Lutsch G, Stahl J, Bielka H (1992). "Eukaryotic initiation factors eIF-2 and eIF-3: interactions, structure and localization in ribosomal initiation complexes". Biochimie. 73 (7-8): 1007–19. doi:10.1016/0300-9084(91)90142-N. PMID 1742346.
• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11-12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Zhang XT, Tan YM, Tan YH (1990). "Isolation of a cDNA encoding human 40S ribosomal protein s3". Nucleic Acids Res. 18 (22): 6689. doi:10.1093/nar/18.22.6689. PMC 332635. PMID 2129557.
• Kim J, Chubatsu LS, Admon A, Stahl J, Fellous R, Linn S (1995). "Implication of mammalian ribosomal protein S3 in the processing of DNA damage". J. Biol. Chem. 270 (23): 13620–9. doi:10.1074/jbc.270.23.13620. PMID 7775413.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Tycowski KT, Shu MD, Steitz JA (1993). "A small nucleolar RNA is processed from an intron of the human gene encoding ribosomal protein S3". Genes Dev. 7 (7A): 1176–90. doi:10.1101/gad.7.7a.1176. PMID 8319909.
• Vladimirov SN, Ivanov AV, Karpova GG, Musolyamov AK, Egorov TA, Thiede B, Wittmann-Liebold B, Otto A (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
• Yoshihama M, Uechi T, Asakawa S, Kawasaki K, Kato S, Higa S, Maeda N, Minoshima S, Tanaka T, Shimizu N, Kenmochi N (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
• Lee CH, Kim SH, Choi JI, Choi JY, Lee CE, Kim J (2002). "Electron paramagnetic resonance study reveals a putative iron-sulfur cluster in human rpS3 protein". Mol. Cells. 13 (1): 154–6. PMID 11911468.
• Lim Y, Lee SM, Kim M, Lee JY, Moon EP, Lee BJ, Kim J (2002). "Complete genomic structure of human rpS3: identification of functional U15b snoRNA in the fifth intron". Gene. 286 (2): 291–7. doi:10.1016/S0378-1119(02)00502-4. PMID 11943484.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Jang CY, Lee JY, Kim J (2004). "RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis". FEBS Lett. 560 (1-3): 81–5. doi:10.1016/S0014-5793(04)00074-2. PMID 14988002.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.