SBF1

SBF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V5U
Identifiers
Aliases	SBF1, CMT4B3, DENND7A, MTMR5, SET binding factor 1
External IDs	MGI: 1925230 HomoloGene: 84710 GeneCards: SBF1
Gene ontology Molecular function • phosphatase regulator activity • Rab guanyl-nucleotide exchange factor activity • protein tyrosine/serine/threonine phosphatase activity • guanyl-nucleotide exchange factor activity Cellular component • integral component of membrane • nucleus Biological process • regulation of GTPase activity • protein dephosphorylation • spermatogenesis • positive regulation of GTPase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6305	77980
Ensembl	ENSG00000100241	ENSMUSG00000036529
UniProt	O95248	Q6ZPE2
RefSeq (mRNA)	NM_002972	NM_001081030 NM_001170561 NM_030019
RefSeq (protein)	NP_002963.2	NP_001074499.2 NP_001164032.1
Location (UCSC)	Chr 22: 50.45 – 50.48 Mb	Chr 15: 89.29 – 89.32 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Myotubularin-related protein 5 is a protein that in humans is encoded by the SBF1 gene.^[3][4][5]

Interactions

SBF1 has been shown to interact with MTMR2^[6] and SUV39H1.^[7]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Cui X, De Vivo I, Slany R, Miyamoto A, Firestein R, Cleary ML (April 1998). "Association of SET domain and myotubularin-related proteins modulates growth control". Nat. Genet. 18 (4): 331–7. doi:10.1038/ng0498-331. PMID 9537414.
4. Laporte J, Blondeau F, Buj-Bello A, Tentler D, Kretz C, Dahl N, Mandel JL (December 1998). "Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human". Hum. Mol. Genet. 7 (11): 1703–12. doi:10.1093/hmg/7.11.1703. PMID 9736772.
5. "Entrez Gene: SBF1 SET binding factor 1".
6. Kim SA, Vacratsis PO, Firestein R, Cleary ML, Dixon JE (April 2003). "Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4492–7. doi:10.1073/pnas.0431052100. PMC 153583. PMID 12668758.
7. Firestein R, Cui X, Huie P, Cleary ML (July 2000). "Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9". Mol. Cell. Biol. 20 (13): 4900–9. doi:10.1128/MCB.20.13.4900-4909.2000. PMC 85941. PMID 10848615.

Further reading

• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Firestein R, Cui X, Huie P, Cleary ML (2000). "Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9". Mol. Cell. Biol. 20 (13): 4900–9. doi:10.1128/MCB.20.13.4900-4909.2000. PMC 85941. PMID 10848615.
• Firestein R, Cleary ML (2001). "Pseudo-phosphatase Sbf1 contains an N-terminal GEF homology domain that modulates its growth regulatory properties". J. Cell. Sci. 114 (Pt 16): 2921–7. PMID 11686296.
• Firestein R, Nagy PL, Daly M, Huie P, Conti M, Cleary ML (2002). "Male infertility, impaired spermatogenesis, and azoospermia in mice deficient for the pseudophosphatase Sbf1". J. Clin. Invest. 109 (9): 1165–72. doi:10.1172/JCI12589. PMC 150957. PMID 11994405.
• Kim SA, Vacratsis PO, Firestein R, Cleary ML, Dixon JE (2003). "Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4492–7. doi:10.1073/pnas.0431052100. PMC 153583. PMID 12668758.