SCG3

SCG3
Identifiers
Aliases	SCG3, SGIII, secretogranin III
External IDs	MGI: 103032 HomoloGene: 7526 GeneCards: SCG3
Gene ontology Molecular function • poly(A) RNA binding Cellular component • extracellular region • secretory granule lumen • transport vesicle membrane • membrane • cytoplasmic, membrane-bounded vesicle • cytoplasmic vesicle Biological process • platelet degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	29106	20255
Ensembl	ENSG00000104112	ENSMUSG00000032181
UniProt	Q8WXD2	P47867
RefSeq (mRNA)	NM_013243 NM_001165257	NM_001164790 NM_009130
RefSeq (protein)	NP_001158729.1 NP_037375.2	NP_001158262.1 NP_033156.1
Location (UCSC)	Chr 15: 51.68 – 51.72 Mb	Chr 9: 75.64 – 75.68 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Secretogranin III, also known as SCG3, is a protein which in humans is encoded by the SCG3 gene.^[3][4]

Function

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Rong YP; Liu F; Zeng LC; Ma WJ; Wei DZ; Han ZG (July 2002). "Cloning and characterization of a novel human secretory protein: secretogranin III". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 34 (4): 411–7. PMID 12098761.
4. "Entrez Gene: SCG3 secretogranin III".

Further reading

• Huttner WB; Gerdes HH; Rosa P (1991). "The granin (chromogranin/secretogranin) family". Trends Biochem. Sci. 16 (1): 27–30. doi:10.1016/0968-0004(91)90012-K. PMID 2053134.
• Ozawa H; Takata K (1996). "The granin family--its role in sorting and secretory granule formation". Cell Struct. Funct. 20 (6): 415–420. doi:10.1247/csf.20.415. PMID 8825061.
• Dopazo A, Lovenberg TW, Danielson PE, et al. (1994). "Primary structure of mouse secretogranin III and its absence from deficient mice". J. Mol. Neurosci. 4 (4): 225–233. doi:10.1007/BF02821554. PMID 7917832.
• Holthuis JC; Jansen EJ; Martens GJ (1996). "Secretogranin III is a sulfated protein undergoing proteolytic processing in the regulated secretory pathway". J. Biol. Chem. 271 (30): 17755–17760. doi:10.1074/jbc.271.30.17755. PMID 8663421.
• Rong YP, Liu F, Zeng LC, et al. (2002). "Cloning and characterization of a novel human secretory protein: secretogranin III". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 34 (4): 411–7. PMID 12098761.
• Hosaka M, Watanabe T, Sakai Y, et al. (2003). "Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells". Mol. Biol. Cell. 13 (10): 3388–3399. doi:10.1091/mbc.02-03-0040. PMC 129953. PMID 12388744.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sakai Y, Hosaka M, Hira Y, et al. (2003). "Immunocytochemical localization of secretogranin III in the anterior lobe of male rat pituitary glands". J. Histochem. Cytochem. 51 (2): 227–38. doi:10.1177/002215540305100211. PMID 12533531.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Hosaka M, Suda M, Sakai Y, et al. (2004). "Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A". J. Biol. Chem. 279 (5): 3627–3634. doi:10.1074/jbc.M310104200. PMID 14597614.
• Sakai Y, Hosaka M, Yoshinaga A, et al. (2004). "Immunocytochemical localization of secretogranin III in the endocrine pancreas of male rats". Arch. Histol. Cytol. 67 (1): 57–64. doi:10.1679/aohc.67.57. PMID 15125023.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–126. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Tanabe A, Yanagiya T, Iida A, et al. (2007). "Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity". J. Clin. Endocrinol. Metab. 92 (3): 1145–1154. doi:10.1210/jc.2006-1808. PMID 17200173.