Secretagogin

SCGN
Identifiers
Aliases	SCGN, CALBL, DJ501N12.8, SECRET, SEGN, setagin, secretagogin, EF-hand calcium binding protein
External IDs	MGI: 2384873 HomoloGene: 5088 GeneCards: SCGN
Gene ontology Molecular function • calcium ion binding • metal ion binding Cellular component • cytoplasm • extracellular region • neuron projection • cytosol • transport vesicle membrane • synapse • membrane • cytoplasmic vesicle • nucleus Biological process • regulation of cytosolic calcium ion concentration • biological process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10590	214189
Ensembl	ENSG00000079689	ENSMUSG00000021337
UniProt	O76038	Q91WD9
RefSeq (mRNA)	NM_006998	NM_145399
RefSeq (protein)	NP_008929.2	NP_663374.1
Location (UCSC)	Chr 6: 25.65 – 25.7 Mb	Chr 13: 23.95 – 23.99 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Secretagogin is a protein that in humans is encoded by the SCGN gene.^[3][4]

Function

The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in potassium chloride-stimulated calcium flux and cell proliferation.^[4] This protein plays an important role in the release of the stress hormone Corticotropin-releasing hormone (CRH) and which only then enables stress processes in the brain.

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Wagner L; Oliyarnyk O; Gartner W; Nowotny P; Groeger M; Kaserer K; Waldhausl W; Pasternack MS (Sep 2000). "Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein". J Biol Chem. 275 (32): 24740–51. doi:10.1074/jbc.M001974200. PMID 10811645.
4. "Entrez Gene: SCGN secretagogin, EF-hand calcium binding protein".

Further reading

• Gartner W, Lang W, Leutmetzer F, et al. (2002). "Cerebral expression and serum detectability of secretagogin, a recently cloned EF-hand Ca(2+)-binding protein.". Cereb. Cortex. 11 (12): 1161–9. doi:10.1093/cercor/11.12.1161. PMID 11709487.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Zhan X; Evans CO; Oyesiku NM; Desiderio DM (2004). "Proteomics and transcriptomics analyses of secretagogin down-regulation in human non-functional pituitary adenomas.". Pituitary. 6 (4): 189–202. doi:10.1023/B:PITU.0000023426.99808.40. PMID 15237930.
• Zierhut B, Daneva T, Gartner W, et al. (2005). "Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene.". Biochem. Biophys. Res. Commun. 329 (4): 1193–9. doi:10.1016/j.bbrc.2005.02.093. PMID 15766553.
• Skovhus KV, Bergholdt R, Erichsen C, et al. (2007). "Identification and characterization of secretagogin promoter activity.". Scand. J. Immunol. 64 (6): 639–45. doi:10.1111/j.1365-3083.2006.01854.x. PMID 17083620.
• Romanov R.; Alpar A.; et al. (2014). "A secretagogin locus of the mammalian hypothalamus controls stress hormone release.". EMBO Journal. 34: 36–54. doi:10.15252/embj.201488977.