SEC24C

SEC24C
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3EH2
Identifiers
Aliases	SEC24C
External IDs	MGI: 1919746 HomoloGene: 3615 GeneCards: SEC24C
Gene ontology Molecular function • zinc ion binding • protein binding • molecular function Cellular component • cytoplasm • cytosol • Golgi apparatus • endoplasmic reticulum membrane • membrane • Golgi membrane • endoplasmic reticulum • perinuclear region of cytoplasm • COPII vesicle coat • ER to Golgi transport vesicle membrane Biological process • antigen processing and presentation of exogenous peptide antigen via MHC class II • antigen processing and presentation of peptide antigen via MHC class I • ER to Golgi vesicle-mediated transport • COPII vesicle coating • transport • protein transport • intracellular protein transport • vesicle-mediated transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9632	218811
Ensembl	ENSG00000176986	ENSMUSG00000039367
UniProt	P53992	n/a
RefSeq (mRNA)	NM_004922 NM_198597	NM_001168273 NM_172596
RefSeq (protein)	NP_004913.2 NP_940999.1	n/a
Location (UCSC)	Chr 10: 73.74 – 73.77 Mb	Chr 14: 20.67 – 20.69 Mb
PubMed search	[1]	[2]
Wikidata

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Protein transport protein Sec24C is a protein that in humans is encoded by the SEC24C gene.^[3][4][5]

Function

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified.^[5]

Interactions

SEC24C has been shown to interact with SEC23A.^[6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Tani K, Oyama Y, Hatsuzawa K, Tagaya M (May 1999). "Hypothetical protein KIAA0079 is a mammalian homologue of yeast Sec24p". FEBS Lett. 447 (2-3): 247–50. doi:10.1016/S0014-5793(99)00303-8. PMID 10214955.
4. Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044. Check date values in: |year= / |date= mismatch (help)
5. "Entrez Gene: SEC24C SEC24 related gene family, member C (S. cerevisiae)".
6. Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L, Paccaud JP (Mar 1999). "Sec24 proteins and sorting at the endoplasmic reticulum". J. Biol. Chem. 274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. PMID 10075675.

Further reading

• Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L, Paccaud JP (1999). "Sec24 proteins and sorting at the endoplasmic reticulum". J. Biol. Chem. 274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. PMID 10075675.
• Tang BL, Kausalya J, Low DY, Lock ML, Hong W (1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem. Biophys. Res. Commun. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.
• Dudognon P, Maeder-Garavaglia C, Carpentier JL, Paccaud JP (2004). "Regulation of a COPII component by cytosolic O-glycosylation during mitosis". FEBS Lett. 561 (1-3): 44–50. doi:10.1016/S0014-5793(04)00109-7. PMID 15013749.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.