SECISBP2

SECISBP2
Identifiers
Aliases	SECISBP2, SBP2, SECIS binding protein 2
External IDs	MGI: 1922670 HomoloGene: 11415 GeneCards: SECISBP2
Gene ontology Molecular function • RNA binding • selenocysteine insertion sequence binding • poly(A) RNA binding • ribonucleoprotein complex binding • mRNA 3'-UTR binding • protein binding Cellular component • nucleus • nucleoplasm • intracellular ribonucleoprotein complex • mitochondrion Biological process • translation • striatum development • selenocysteine incorporation • neuron development • negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79048	75420
Ensembl	ENSG00000187742	ENSMUSG00000035139
UniProt	Q96T21	n/a
RefSeq (mRNA)	NM_001282688 NM_001282689 NM_001282690 NM_024077	NM_029279 NM_001308448
RefSeq (protein)	NP_001269617.1 NP_001269618.1 NP_076982.3	n/a
Location (UCSC)	Chr 9: 89.32 – 89.36 Mb	Chr 13: 51.65 – 51.68 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

SECIS-binding protein 2 (commonly referred to as SBP2) is a protein that in humans is encoded by the SECISBP2 gene.^[3][4]

Function

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. SBP2 is a nuclear protein that functions as a SECIS binding protein, but experimental evidence indicates that SBP2 is cytoplasmic.^[4]

Clinical significance

Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.^[4]

See also

• Thyroid hormone resistance

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Wiemann S; Weil B; Wellenreuther R; Gassenhuber J; Glassl S; Ansorge W; Bocher M; Blocker H; Bauersachs S; Blum H; Lauber J; Dusterhoft A; Beyer A; Kohrer K; Strack N; Mewes HW; Ottenwalder B; Obermaier B; Tampe J; Heubner D; Wambutt R; Korn B; Klein M; Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
4. "Entrez Gene: SECISBP2 SECIS binding protein 2".

Further reading

• Bonaldo MF; Lennon G; Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Copeland PR, Fletcher JE, Carlson BA, et al. (2000). "A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs". EMBO J. 19 (2): 306–14. doi:10.1093/emboj/19.2.306. PMC 305564. PMID 10637234.
• Hartley JL; Temple GF; Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Low SC; Grundner-Culemann E; Harney JW; Berry MJ (2001). "SECIS–SBP2 interactions dictate selenocysteine incorporation efficiency and selenoprotein hierarchy". EMBO J. 19 (24): 6882–90. doi:10.1093/emboj/19.24.6882. PMC 305907. PMID 11118223.
• Lescure A, Allmang C, Yamada K, et al. (2002). "cDNA cloning, expression pattern and RNA binding analysis of human selenocysteine insertion sequence (SECIS) binding protein 2". Gene. 291 (1–2): 279–85. doi:10.1016/S0378-1119(02)00629-7. PMID 12095701.
• Allmang C; Carbon P; Krol A (2002). "The SBP2 and 15.5 kD/Snu13p proteins share the same RNA binding domain: identification of SBP2 amino acids important to SECIS RNA binding". RNA. 8 (10): 1308–18. doi:10.1017/S1355838202020034. PMC 1370339. PMID 12403468.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Dumitrescu AM, Liao XH, Abdullah MS, et al. (2006). "Mutations in SECISBP2 result in abnormal thyroid hormone metabolism". Nat. Genet. 37 (11): 1247–52. doi:10.1038/ng1654. PMID 16228000.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Papp LV, Lu J, Striebel F, et al. (2006). "The Redox State of SECIS Binding Protein 2 Controls Its Localization and Selenocysteine Incorporation Function". Mol. Cell. Biol. 26 (13): 4895–910. doi:10.1128/MCB.02284-05. PMC 1489162. PMID 16782878.