SEMA3C

SEMA3C
Identifiers
Aliases	SEMA3C, SEMAE, SemE, semaphorin 3C
External IDs	MGI: 107557 HomoloGene: 36201 GeneCards: SEMA3C
Gene ontology Molecular function • semaphorin receptor binding • neuropilin binding • chemorepellent activity Cellular component • extracellular fluid • extracellular region • extracellular exosome Biological process • somitogenesis • cell differentiation • negative chemotaxis • limb bud formation • positive regulation of cell migration • outflow tract morphogenesis • post-embryonic development • negative regulation of axon extension involved in axon guidance • nervous system development • axon guidance • multicellular organism development • heart development • blood vessel remodeling • pulmonary myocardium development • neural crest cell migration • immune response • neural tube development • dichotomous subdivision of terminal units involved in salivary gland branching • cardiac right ventricle morphogenesis • semaphorin-plexin signaling pathway • response to drug Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10512	20348
Ensembl	ENSG00000075223	ENSMUSG00000028780
UniProt	Q99985	Q62181
RefSeq (mRNA)	NM_006379	NM_013657
RefSeq (protein)	NP_006370.1	NP_038685.3
Location (UCSC)	Chr 7: 80.74 – 80.92 Mb	Chr 5: 17.57 – 17.73 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Semaphorin-3C is a protein that in humans is encoded by the SEMA3C gene.^[3][4][5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Puschel AW; Adams RH; Betz H (Jun 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–948. doi:10.1016/0896-6273(95)90332-1. PMID 7748561.
4. Mangasser-Stephan K; Dooley S; Welter C; Mutschler W; Hanselmann RG (Jun 1997). "Identification of human semaphorin E gene expression in rheumatoid synovial cells by mRNA differential display". Biochem Biophys Res Commun. 234 (1): 153–156. doi:10.1006/bbrc.1997.6607. PMID 9168980.
5. "Entrez Gene: SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C".

Further reading

• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
• Bonaldo MF; Lennon G; Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Chen H, Chédotal A, He Z, et al. (1997). "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III". Neuron. 19 (3): 547–559. doi:10.1016/S0896-6273(00)80371-2. PMID 9331348.
• Yamada T; Endo R; Gotoh M; Hirohashi S (1998). "Identification of semaphorin E as a non-MDR drug resistance gene of human cancers". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14713–14718. doi:10.1073/pnas.94.26.14713. PMC 25101. PMID 9405678.
• Galani E, Sgouros J, Petropoulou C, et al. (2002). "Correlation of MDR-1, nm23-H1 and H Sema E gene expression with histopathological findings and clinical outcome in ovarian and breast cancer patients". Anticancer Res. 22 (4): 2275–80. PMID 12174914.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–772. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Rieger J; Wick W; Weller M (2003). "Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins". Glia. 42 (4): 379–389. doi:10.1002/glia.10210. PMID 12730958.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–164. doi:10.1038/nature01782. PMID 12853948.
• Miller LE, Weidler C, Falk W, et al. (2004). "Increased prevalence of semaphorin 3C, a repellent of sympathetic nerve fibers, in the synovial tissue of patients with rheumatoid arthritis". Arthritis Rheum. 50 (4): 1156–1163. doi:10.1002/art.20110. PMID 15077297. replacement character in |first6= at position 2 (help); replacement character in |last6= at position 4 (help)
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beckers J, Herrmann F, Rieger S, et al. (2005). "Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis". Int. J. Cancer. 114 (4): 590–597. doi:10.1002/ijc.20798. PMID 15609325.
• Herman JG; Meadows GG (2007). "Increased class 3 semaphorin expression modulates the invasive and adhesive properties of prostate cancer cells". Int. J. Oncol. 30 (5): 1231–8. doi:10.3892/ijo.30.5.1231. PMID 17390026.