SEMA4C

SEMA4C
Identifiers
Aliases	SEMA4C, M-SEMA-F, SEMACL1, SEMAF, SEMAI, semaphorin 4C
External IDs	MGI: 109252 HomoloGene: 23047 GeneCards: SEMA4C
Gene ontology Molecular function • semaphorin receptor binding • protein binding • neuropilin binding • chemorepellent activity Cellular component • integral component of membrane • postsynaptic membrane • membrane • postsynaptic density • plasma membrane • synapse • synaptic vesicle membrane • extracellular fluid • cell junction • cytoplasmic vesicle Biological process • cell differentiation • negative chemotaxis • positive regulation of cell migration • cell migration in hindbrain • cerebellum development • negative regulation of axon extension involved in axon guidance • nervous system development • multicellular organism development • muscle cell differentiation • neural tube closure • neural crest cell migration • semaphorin-plexin signaling pathway • positive regulation of stress-activated MAPK cascade Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54910	20353
Ensembl	ENSG00000168758	ENSMUSG00000026121
UniProt	Q9C0C4	Q64151
RefSeq (mRNA)	NM_017789	NM_001126047 NM_001304329 NM_001304330
RefSeq (protein)	NP_060259.4	NP_001119519.1 NP_001291258.1 NP_001291259.1
Location (UCSC)	Chr 2: 96.86 – 96.87 Mb	Chr 1: 36.55 – 36.56 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

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Semaphorin-4C is a protein that in humans is encoded by the SEMA4C gene.^[3][4]

Interactions

SEMA4C has been shown to interact with DLG4.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Inagaki S, Furuyama T, Iwahashi Y (October 1995). "Identification of a member of mouse semaphorin family". FEBS Lett. 370 (3): 269–72. doi:10.1016/0014-5793(95)00850-9. PMID 7656991.
4. "Entrez Gene: SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C".
5. Inagaki S, Ohoka Y, Sugimoto H, Fujioka S, Amazaki M, Kurinami H, Miyazaki N, Tohyama M, Furuyama T (March 2001). "Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95". J. Biol. Chem. 276 (12): 9174–81. doi:10.1074/jbc.M009051200. PMID 11134026.

Further reading

• Simmons AD, Püschel AW, McPherson JD, Overhauser J, Lovett M (1998). "Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval.". Biochem. Biophys. Res. Commun. 242 (3): 685–91. doi:10.1006/bbrc.1997.8027. PMID 9464278.
• Wang LH, Kalb RG, Strittmatter SM (1999). "A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF.". J. Biol. Chem. 274 (20): 14137–46. doi:10.1074/jbc.274.20.14137. PMID 10318831.
• Inagaki S, Ohoka Y, Sugimoto H, Fujioka S, Amazaki M, Kurinami H, Miyazaki N, Tohyama M, Furuyama T (2001). "Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95.". J. Biol. Chem. 276 (12): 9174–81. doi:10.1074/jbc.M009051200. PMID 11134026.
• Ohoka Y, Hirotani M, Sugimoto H, Fujioka S, Furuyama T, Inagaki S (2001). "Semaphorin 4C, a transmembrane semaphorin, [corrected] associates with a neurite-outgrowth-related protein, SFAP75.". Biochem. Biophys. Res. Commun. 280 (1): 237–43. doi:10.1006/bbrc.2000.4080. PMID 11162505.
• Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.