SEMA5A

SEMA5A
Identifiers
Aliases	SEMA5A, SEMAF, semF, semaphorin 5A
External IDs	MGI: 107556 HomoloGene: 2949 GeneCards: SEMA5A
Genetically Related Diseases
obesity, Parkinson's disease[1]
Gene ontology Molecular function • chondroitin sulfate proteoglycan binding • semaphorin receptor binding • heparan sulfate proteoglycan binding • syndecan binding • chemorepellent activity Cellular component • integral component of membrane • membrane • plasma membrane • extracellular exosome Biological process • negative regulation of endothelial cell apoptotic process • negative regulation of cell adhesion • cell differentiation • positive regulation of protein kinase B signaling • positive regulation of endothelial cell proliferation • positive regulation of cell migration • positive regulation of catenin import into nucleus • positive regulation of endothelial cell chemotaxis • cell-cell signaling • positive regulation of axon extension involved in axon guidance • blood vessel endothelial cell proliferation involved in sprouting angiogenesis • nervous system development • positive regulation of angiogenesis • negative regulation of axon extension involved in axon guidance • multicellular organism development • diencephalon development • cell adhesion • neural crest cell migration • signal clustering • cell chemotaxis • positive chemotaxis • axonal fasciculation • positive regulation of actin filament depolymerization • semaphorin-plexin signaling pathway • negative chemotaxis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9037	20356
Ensembl	ENSG00000112902	ENSMUSG00000022231
UniProt	Q13591	Q62217
RefSeq (mRNA)	NM_003966	NM_009154
RefSeq (protein)	NP_003957.2	n/a
Location (UCSC)	Chr 5: 9.04 – 9.55 Mb	Chr 15: 32.24 – 32.7 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Semaphorin-5A is a protein that in humans is encoded by the SEMA5A gene.^[4][5][6]

Members of the semaphorin protein family, such as SEMA5A, are involved in axonal guidance during neural development (Adams et al., 1996).[supplied by OMIM]^[6]

Semaphorine 5A also plays a role in autism, reducing the ability of neurons to form connections with other neurons in certain brain regions (needs citation).

References

1. "Diseases that are genetically associated with SEMA5A view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Adams RH, Betz H, Puschel AW (Feb 1997). "A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis". Mech Dev. 57 (1): 33–45. doi:10.1016/0925-4773(96)00525-4. PMID 8817451.
5. Simmons AD, Puschel AW, McPherson JD, Overhauser J, Lovett M (Mar 1998). "Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval". Biochem Biophys Res Commun. 242 (3): 685–91. doi:10.1006/bbrc.1997.8027. PMID 9464278.
6. "Entrez Gene: SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Simmons AD, Overhauser J, Lovett M (1997). "Isolation of cDNAs from the Cri-du-chat critical region by direct screening of a chromosome 5-specific cDNA library.". Genome Res. 7 (2): 118–27. doi:10.1101/gr.7.2.118. PMID 9049630.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Artigiani S, Conrotto P, Fazzari P, et al. (2005). "Plexin-B3 is a functional receptor for semaphorin 5A.". EMBO Rep. 5 (7): 710–4. doi:10.1038/sj.embor.7400189. PMC 1299100. PMID 15218527.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5.". Nature. 431 (7006): 268–74. doi:10.1038/nature02919. PMID 15372022.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Melin M, Carlsson B, Anckarsater H, et al. (2007). "Constitutional downregulation of SEMA5A expression in autism.". Neuropsychobiology. 54 (1): 64–9. doi:10.1159/000096040. PMC 2553518. PMID 17028446.