SEPT10

SEPT10
Identifiers
Aliases	SEPT10
External IDs	MGI: 1918110 HomoloGene: 27035 GeneCards: SEPT10
Gene ontology Molecular function • nucleotide binding • GTP binding • protein binding Cellular component • cytoplasm • cytoskeleton Biological process • cell cycle • cell division Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	151011	103080
Ensembl	ENSG00000186522	ENSMUSG00000019917
UniProt	Q9P0V9	Q8C650
RefSeq (mRNA)	NM_144710 NM_178584 NM_001321496 NM_001321498 NM_001321499 NM_001321500 NM_001321501 NM_001321502 NM_001321503 NM_001321504 NM_001321505 NM_001321506 NM_001321507 NM_001321508 NM_001321509 NM_001321510 NM_001321511 NM_001321512 NM_001321513 NM_001321514 NM_001321515	NM_001024910 NM_001024911
RefSeq (protein)	NP_653311.1 NP_848699.1 NP_001308425.1 NP_001308427.1 NP_001308428.1 NP_001308429.1 NP_001308430.1 NP_001308431.1 NP_001308432.1 NP_001308433.1 NP_001308434.1 NP_001308435.1 NP_001308436.1 NP_001308437.1 NP_001308438.1 NP_001308439.1 NP_001308440.1 NP_001308441.1 NP_001308427.1	NP_001020081.2 NP_001020082.1
Location (UCSC)	Chr 2: 109.54 – 109.61 Mb	Chr 10: 59.16 – 59.22 Mb
PubMed search	[1]	[2]
Wikidata

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Septin 10 is a protein that in humans is encoded by the SEPT10 gene.^[3]

Function

This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. Alternative splicing results in multiple transcript variants.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: Septin 10".

Further reading

• Sui L, Zhang W, Liu Q, Chen T, Li N, Wan T, Yu M, Cao X (May 2003). "Cloning and functional characterization of human septin 10, a novel member of septin family cloned from dendritic cells". Biochemical and Biophysical Research Communications. 304 (2): 393–8. doi:10.1016/s0006-291x(03)00601-6. PMID 12711328.
• Benedetti D, Bomben R, Dal-Bo M, Marconi D, Zucchetto A, Degan M, Forconi F, Del-Poeta G, Gaidano G, Gattei V (January 2008). "Are surrogates of IGHV gene mutational status useful in B-cell chronic lymphocytic leukemia? The example of Septin-10". Leukemia. 22 (1): 224–6. doi:10.1038/sj.leu.2404867. PMID 17657217.
• Xu M, Takanashi M, Oikawa K, Nishi H, Isaka K, Yoshimoto T, Ohyashiki J, Kuroda M (April 2012). "Identification of a novel role of Septin 10 in paclitaxel-resistance in cancers through a functional genomics screen". Cancer Science. 103 (4): 821–7. doi:10.1111/j.1349-7006.2012.02221.x. PMID 22320903.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.