SEPW1

SEPW1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NPB
Identifiers
Aliases	SEPW1, selW, selenoprotein W, 1
External IDs	MGI: 1100878 HomoloGene: 2263 GeneCards: SEPW1
Gene ontology Molecular function • antioxidant activity Cellular component • cytoplasm Biological process • cellular oxidant detoxification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6415	20364
Ensembl	ENSG00000178980	ENSMUSG00000041571
UniProt	P63302	P63300
RefSeq (mRNA)	NM_003009	NM_009156
RefSeq (protein)	NP_003000.1	NP_033182.1
Location (UCSC)	Chr 19: 47.78 – 47.78 Mb	Chr 7: 15.92 – 15.92 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Selenoprotein W is a protein that in humans is encoded by the SEPW1 gene.^[3][4]

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein shows highest expression in skeletal muscle and heart, and may be involved in oxidation-reduction reactions. A retroprocessed pseudogene, SEPW1P, has been identified and mapped to chromosome 1p35-34.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Gu QP; Beilstein MA; Vendeland SC; Lugade A; Ream W; Whanger PD (Sep 1997). "Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species". Gene. 193 (2): 187–96. doi:10.1016/S0378-1119(97)00113-3. PMID 9256076.
4. "Entrez Gene: SEPW1 selenoprotein W, 1".

Further reading

• Whanger PD (2001). "Selenoprotein W: a review". Cell. Mol. Life Sci. 57 (13–14): 1846–52. doi:10.1007/PL00000666. PMID 11215511.
• Yeh JY; Beilstein MA; Andrews JS; Whanger PD (1995). "Tissue distribution and influence of selenium status on levels of selenoprotein W". FASEB J. 9 (5): 392–6. PMID 7896009.
• Smith JS, Tachibana I, Pohl U, et al. (2000). "A transcript map of the chromosome 19q-arm glioma tumor suppressor region". Genomics. 64 (1): 44–50. doi:10.1006/geno.1999.6101. PMID 10708517.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kryukov GV, Castellano S, Novoselov SV, et al. (2003). "Characterization of mammalian selenoproteomes". Science. 300 (5624): 1439–43. doi:10.1126/science.1083516. PMID 12775843.
• Bellingham J; Gregory-Evans K; Fox MF; Gregory-Evans CY (2003). "Gene structure and tissue expression of human selenoprotein W, SEPW1, and identification of a retroprocessed pseudogene, SEPW1P". Biochim. Biophys. Acta. 1627 (2–3): 140–6. doi:10.1016/s0167-4781(03)00078-2. PMID 12818432.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Pagmantidis V, Bermano G, Villette S, et al. (2005). "Effects of Se-depletion on glutathione peroxidase and selenoprotein W gene expression in the colon". FEBS Lett. 579 (3): 792–6. doi:10.1016/j.febslet.2004.12.042. PMID 15670848.
• Kim YJ; Chai YG; Ryu JC (2005). "Selenoprotein W as molecular target of methylmercury in human neuronal cells is down-regulated by GSH depletion". Biochem. Biophys. Res. Commun. 330 (4): 1095–102. doi:10.1016/j.bbrc.2005.03.080. PMID 15823556.