SH3KBP1

SH3KBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BZ8, 2K6D, 2K9G, 2O2O, 2YDL, 5ABS, 2N64
Identifiers
Aliases	SH3KBP1, CD2BP3, CIN85, GIG10, HSB-1, HSB1, MIG18, SH3 domain containing kinase binding protein 1
External IDs	MGI: 1889583 HomoloGene: 10971 GeneCards: SH3KBP1
Gene ontology Molecular function • SH3 domain binding • protein binding Cellular component • cytosol • membrane • cell-cell junction • focal adhesion • plasma membrane • endocytic vesicle • synapse • cell junction • neuron projection • cytoskeleton • cytoplasmic vesicle membrane • cytoplasmic vesicle • cytoplasm Biological process • negative regulation of epidermal growth factor receptor signaling pathway • endocytosis • cell-cell signaling • cytoskeleton organization • regulation of cell shape • cell migration • apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	30011	58194
Ensembl	ENSG00000147010	ENSMUSG00000040990
UniProt	Q96B97 Q5JPT2	Q8R550
RefSeq (mRNA)	NM_001024666 NM_001184960 NM_031892	NM_001135727 NM_001135728 NM_001290661 NM_001290664 NM_021389
RefSeq (protein)	NP_001019837.1 NP_001171889.1 NP_114098.1	NP_001129199.1 NP_001129200.1 NP_001277590.1 NP_001277593.1 NP_067364.2
Location (UCSC)	Chr X: 19.53 – 19.89 Mb	Chr X: 159.63 – 159.98 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

SH3 domain-containing kinase-binding protein 1 is an enzyme that in humans is encoded by the SH3KBP1 gene.^[3][4]

CBL (MIM 165360) constitutively interacts with SH3 domain-containing proteins and, upon tyrosine phosphorylation, with SH2 domain-containing proteins. The SH3KBP1 gene encodes an 85-kD CBL-interacting protein that enhances tumor necrosis factor (MIM 191160)-mediated apoptotic cell death (Narita et al., 2001).[supplied by OMIM]^[5]

Interactions

SH3KBP1 has been shown to interact with B-cell linker,^[6] Grb2,^[7][8] SH3GLB2,^[9][10] SH3GL3,^[9] SH3GL2,^[10] BCAR1,^[6] Epidermal growth factor receptor,^[10][11] CBLB,^[11] Cbl gene,^{[6][8][9][10][11]} SOS1,^[6] CRK^[6] and PAK2.^[12]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Hillier LD; Lennon G; Becker M; Bonaldo MF; Chiapelli B; Chissoe S; Dietrich N; DuBuque T; Favello A; Gish W; Hawkins M; Hultman M; Kucaba T; Lacy M; Le M; Le N; Mardis E; Moore B; Morris M; Parsons J; Prange C; Rifkin L; Rohlfing T; Schellenberg K; Bento Soares M; Tan F; Thierry-Meg J; Trevaskis E; Underwood K; Wohldman P; Waterston R; Wilson R; Marra M (May 1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
4. Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O, et al. (November 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
5. "Entrez Gene: SH3KBP1 SH3-domain kinase binding protein 1".
6. Watanabe, S; Take H; Takeda K; Yu Z X; Iwata N; Kajigaya S (November 2000). "Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes". Biochem. Biophys. Res. Commun. UNITED STATES. 278 (1): 167–74. doi:10.1006/bbrc.2000.3760. ISSN 0006-291X. PMID 11071869.
7. Gout, I; Middleton G; Adu J; Ninkina N N; Drobot L B; Filonenko V; Matsuka G; Davies A M; Waterfield M; Buchman V L (August 2000). "Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein". EMBO J. ENGLAND. 19 (15): 4015–25. doi:10.1093/emboj/19.15.4015. ISSN 0261-4189. PMC 306608. PMID 10921882.
8. Borinstein, S C; Hyatt M A; Sykes V W; Straub R E; Lipkowitz S; Boulter J; Bogler O (December 2000). "SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins". Cell. Signal. ENGLAND. 12 (11–12): 769–79. doi:10.1016/S0898-6568(00)00129-7. ISSN 0898-6568. PMID 11152963.
9. Petrelli, Annalisa; Gilestro Giorgio F; Lanzardo Stefania; Comoglio Paolo M; Migone Nicola; Giordano Silvia (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. England. 416 (6877): 187–90. doi:10.1038/416187a. ISSN 0028-0836. PMID 11894096.
10. Soubeyran, Philippe; Kowanetz Katarzyna; Szymkiewicz Iwona; Langdon Wallace Y; Dikic Ivan (March 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature. England. 416 (6877): 183–7. doi:10.1038/416183a. ISSN 0028-0836. PMID 11894095.
11. Szymkiewicz, Iwona; Kowanetz Katarzyna; Soubeyran Philippe; Dinarina Ana; Lipkowitz Stanley; Dikic Ivan (October 2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases". J. Biol. Chem. United States. 277 (42): 39666–72. doi:10.1074/jbc.M205535200. ISSN 0021-9258. PMID 12177062.
12. Kurakin, Alexei V; Wu Susan; Bredesen Dale E (September 2003). "Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening". J. Biol. Chem. United States. 278 (36): 34102–9. doi:10.1074/jbc.M305264200. ISSN 0021-9258. PMID 12829691.

Further reading

• Salvatore P, Hanash CR, Kido Y, et al. (1998). "Identification of sirm, a novel insulin-regulated SH3 binding protein that associates with Grb-2 and FYN". J. Biol. Chem. 273 (12): 6989–97. doi:10.1074/jbc.273.12.6989. PMID 9507006.
• Li J, Nishizawa K, An W, et al. (1999). "A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion". EMBO J. 17 (24): 7320–36. doi:10.1093/emboj/17.24.7320. PMC 1171078. PMID 9857189.
• Take H, Watanabe S, Takeda K, et al. (2000). "Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl". Biochem. Biophys. Res. Commun. 268 (2): 321–8. doi:10.1006/bbrc.2000.2147. PMID 10679202.
• Chen B, Borinstein SC, Gillis J, et al. (2000). "The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes". J. Biol. Chem. 275 (25): 19275–81. doi:10.1074/jbc.M908994199. PMID 10858458.
• Gout I, Middleton G, Adu J, et al. (2000). "Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein". EMBO J. 19 (15): 4015–25. doi:10.1093/emboj/19.15.4015. PMC 306608. PMID 10921882.
• Watanabe S, Take H, Takeda K, et al. (2001). "Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes". Biochem. Biophys. Res. Commun. 278 (1): 167–74. doi:10.1006/bbrc.2000.3760. PMID 11071869.
• Borinstein SC, Hyatt MA, Sykes VW, et al. (2001). "SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins". Cell. Signal. 12 (11–12): 769–79. doi:10.1016/S0898-6568(00)00129-7. PMID 11152963.
• Narita T, Amano F, Yoshizaki K, et al. (2001). "Assignment of SH3KBP1 to human chromosome band Xp22.1→p21.3 by in situ hybridization". Cytogenet. Cell Genet. 93 (1–2): 133–4. doi:10.1159/000056966. PMID 11474197.
• Soubeyran P, Kowanetz K, Szymkiewicz I, et al. (2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature. 416 (6877): 183–7. doi:10.1038/416183a. PMID 11894095.
• Petrelli A, Gilestro GF, Lanzardo S, et al. (2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096.
• Scott MP, Zappacosta F, Kim EY, et al. (2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1". J. Biol. Chem. 277 (31): 28238–46. doi:10.1074/jbc.M202783200. PMID 12029088.
• Verdier F, Valovka T, Zhyvoloup A, et al. (2002). "Ruk is ubiquitinated but not degraded by the proteasome". Eur. J. Biochem. 269 (14): 3402–8. doi:10.1046/j.1432-1033.2002.03031.x. PMID 12135478.
• Szymkiewicz I, Kowanetz K, Soubeyran P, et al. (2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases". J. Biol. Chem. 277 (42): 39666–72. doi:10.1074/jbc.M205535200. PMID 12177062.
• Haglund K; Shimokawa N; Szymkiewicz I; Dikic I (2002). "Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12191–6. doi:10.1073/pnas.192462299. PMC 129420. PMID 12218189.
• Buchman VL, Luke C, Borthwick EB, et al. (2003). "Organization of the mouse Ruk locus and expression of isoforms in mouse tissues". Gene. 295 (1): 13–17. doi:10.1016/S0378-1119(02)00821-1. PMID 12242006.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tibaldi EV; Reinherz EL (2003). "CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment, but elicit divergent functional activities". Int. Immunol. 15 (3): 313–29. doi:10.1093/intimm/dxg032. PMID 12618476.
• Hutchings NJ, Clarkson N, Chalkley R, et al. (2003). "Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85". J. Biol. Chem. 278 (25): 22396–403. doi:10.1074/jbc.M302540200. PMID 12690097.