SIPA1L1

SIPA1L1
Identifiers
Aliases	SIPA1L1, E6TP1, signal induced proliferation associated 1 like 1
External IDs	MGI: 2443679 HomoloGene: 9189 GeneCards: SIPA1L1
Genetically Related Diseases
obesity[1]
Gene ontology Molecular function • GTPase activator activity • ephrin receptor binding • molecular function Cellular component • cytoplasm • postsynaptic membrane • membrane • postsynaptic density • cellular component • plasma membrane • dendritic spine • synapse • cell junction • neuron projection • cytoskeleton Biological process • actin cytoskeleton reorganization • biological process • activation of GTPase activity • regulation of GTPase activity • ephrin receptor signaling pathway • regulation of synaptic plasticity • regulation of dendrite morphogenesis • regulation of axonogenesis • regulation of small GTPase mediated signal transduction • regulation of dendritic spine morphogenesis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26037	217692
Ensembl	ENSG00000197555	ENSMUSG00000042700
UniProt	O43166	Q8C0T5
RefSeq (mRNA)	NM_001284245 NM_001284246 NM_001284247 NM_015556	NM_001167983 NM_172579
RefSeq (protein)	NP_001271174.1 NP_001271175.1 NP_001271176.1 NP_056371.1	NP_001161455.1 NP_766167.2
Location (UCSC)	Chr 14: 71.32 – 71.74 Mb	Chr 12: 82.17 – 82.45 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Signal-induced proliferation-associated 1-like protein 1 is a protein that in humans is encoded by the SIPA1L1 gene.^[4][5]

References

1. "Diseases that are genetically associated with SIPA1L1 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Gao Q; Srinivasan S; Boyer SN; Wazer DE; Band V (Feb 1999). "The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation". Mol Cell Biol. 19 (1): 733–44. PMC 83930. PMID 9858596.
5. "Entrez Gene: SIPA1L1 signal-induced proliferation-associated 1 like 1".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Lee C; Wooldridge TR; Laimins LA (2007). "Analysis of the roles of E6 binding to E6TP1 and nuclear localization in the human papillomavirus type 31 life cycle". Virology. 358 (1): 201–10. doi:10.1016/j.virol.2006.08.028. PMID 16999984.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Chih DY, Park DJ, Gross M, et al. (2005). "Protein partners of C/EBPepsilon". Exp. Hematol. 32 (12): 1173–81. doi:10.1016/j.exphem.2004.08.014. PMID 15588942.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nakayama M; Kikuno R; Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Pak DT, Yang S, Rudolph-Correia S, et al. (2001). "Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP". Neuron. 31 (2): 289–303. doi:10.1016/S0896-6273(01)00355-5. PMID 11502259.
• Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.