SLC6A14

SLC6A14
Identifiers
Aliases	SLC6A14, BMIQ11, solute carrier family 6 member 14
External IDs	MGI: 1890216 HomoloGene: 38290 GeneCards: SLC6A14
Gene ontology Molecular function • symporter activity • amino acid transmembrane transporter activity • neurotransmitter:sodium symporter activity Cellular component • integral component of plasma membrane • membrane • brush border membrane • vesicle • extracellular exosome • integral component of membrane • plasma membrane Biological process • neurotransmitter transport • amino acid transport • cellular amino acid metabolic process • response to toxic substance • transport • transmembrane transport • amino acid transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11254	56774
Ensembl	ENSG00000268104	ENSMUSG00000031089
UniProt	Q9UN76	Q9JMA9
RefSeq (mRNA)	NM_007231	NM_020049
RefSeq (protein)	NP_009162.1	NP_064433.3
Location (UCSC)	Chr X: 116.44 – 116.46 Mb	Chr X: 21.71 – 21.74 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (SLC6A14) is a protein that in humans is encoded by the SLC6A14 gene.^[3][4]

Function

SLC6A14 is a member of the Na⁺- and Cl⁻-dependent neurotransmitter transporter family and transports both neutral and cationic amino acids in an Na⁺- and Cl⁻-dependent manner.[supplied by OMIM]^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Sloan JL, Mager S (Sep 1999). "Cloning and functional expression of a human Na(+) and Cl(−)-dependent neutral and cationic amino acid transporter B(0+)". J Biol Chem. 274 (34): 23740–5. doi:10.1074/jbc.274.34.23740. PMID 10446133.
4. "Entrez Gene: SLC6A14 solute carrier family 6 (amino acid transporter), member 14".

Further reading

• Ohman M, Oksanen L, Kaprio J, Koskenvuo M, Mustajoki P, Rissanen A, Salmi J, Kontula K, Peltonen L (2000). "Genome-wide scan of obesity in Finnish sibpairs reveals linkage to chromosome Xq24". J. Clin. Endocrinol. Metab. 85 (9): 3183–90. doi:10.1210/jc.85.9.3183. PMID 10999806.
• Sloan JL, Grubb BR, Mager S (2003). "Expression of the amino acid transporter ATB 0+ in lung: possible role in luminal protein removal". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (1): L39–49. doi:10.1152/ajplung.00164.2002 (inactive 2015-01-01). PMID 12388375.
• Suviolahti E, Oksanen LJ, Ohman M, Cantor RM, Ridderstrale M, Tuomi T, Kaprio J, Rissanen A, Mustajoki P, Jousilahti P, Vartiainen E, Silander K, Kilpikari R, Salomaa V, Groop L, Kontula K, Peltonen L, Pajukanta P (2004). "The SLC6A14 gene shows evidence of association with obesity". J. Clin. Invest. 112 (11): 1762–72. doi:10.1172/JCI17491. PMC 281637. PMID 14660752.
• Durand E, Boutin P, Meyre D, Charles MA, Clement K, Dina C, Froguel P (2004). "Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians". Diabetes. 53 (9): 2483–6. doi:10.2337/diabetes.53.9.2483. PMID 15331564.
• Gupta N, Miyauchi S, Martindale RG, Herdman AV, Podolsky R, Miyake K, Mager S, Prasad PD, Ganapathy ME, Ganapathy V (2005). "Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans". Biochim. Biophys. Acta. 1741 (1–2): 215–23. doi:10.1016/j.bbadis.2005.04.002. PMID 15905073.