SLURP1

SLURP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MUP, 2MUO
Identifiers
Aliases	SLURP1, ANUP, ARS, ArsB, LY6LS, MDM, secreted LY6/PLAUR domain containing 1
External IDs	MGI: 1930923 HomoloGene: 10710 GeneCards: SLURP1
Gene ontology Molecular function • cytokine activity Cellular component • extracellular fluid • extracellular exosome • extracellular region Biological process • cell adhesion • negative regulation of keratinocyte proliferation • neuromuscular process controlling posture • locomotory behavior • negative regulation of cell migration • cell activation • negative regulation of cell proliferation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57152	57277
Ensembl	ENSG00000126233	ENSMUSG00000022596
UniProt	P55000	Q9Z0K7
RefSeq (mRNA)	NM_020427	NM_020519
RefSeq (protein)	NP_065160.1	NP_065265.1
Location (UCSC)	Chr 8: 142.74 – 142.74 Mb	Chr 15: 74.72 – 74.73 Mb
PubMed search	[1]	[2]
Wikidata

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Secreted Ly-6/uPAR-related protein 1 is a protein that in humans is encoded by the SLURP1 gene.^[3][4][5]

The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Fischer J, Bouadjar B, Heilig R, Huber M, Lefevre C, Jobard F, Macari F, Bakija-Konsuo A, Ait-Belkacem F, Weissenbach J, Lathrop M, Hohl D, Prud'homme JF (Apr 2001). "Mutations in the gene encoding SLURP-1 in Mal de Meleda". Hum Mol Genet. 10 (8): 875–80. doi:10.1093/hmg/10.8.875. PMID 11285253.
4. Adermann K, Wattler F, Wattler S, Heine G, Meyer M, Forssmann WG, Nehls M (Jul 1999). "Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily". Protein Sci. 8 (4): 810–9. doi:10.1110/ps.8.4.810. PMC 2144295. PMID 10211827.
5. "Entrez Gene: SLURP1 secreted LY6/PLAUR domain containing 1".

Further reading

• Ridge RJ, Sloane NH (1996). "Partial N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP) and the anti-tumour effect of the N-terminal nonapeptide of the unique cytokine present in human granulocytes". Cytokine. 8 (1): 1–5. doi:10.1006/cyto.1996.0001. PMID 8742060.
• Fischer J, Bouadjar B, Heilig R, et al. (1999). "Genetic linkage of Meleda disease to chromosome 8qter". Eur. J. Hum. Genet. 6 (6): 542–7. doi:10.1038/sj.ejhg.5200254. PMID 9887370.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Eckl KM, Stevens HP, Lestringant GG, et al. (2003). "Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates". Hum. Genet. 112 (1): 50–6. doi:10.1007/s00439-002-0838-8. PMID 12483299.
• Marrakchi S, Audebert S, Bouadjar B, et al. (2003). "Novel mutations in the gene encoding secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related protein-1 (SLURP-1) and description of five ancestral haplotypes in patients with Mal de Meleda". J. Invest. Dermatol. 120 (3): 351–5. doi:10.1046/j.1523-1747.2003.12062.x. PMID 12603845.
• Hu G, Yildirim M, Baysal V, et al. (2003). "A recurrent mutation in the ARS (component B) gene encoding SLURP-1 in Turkish families with mal de Meleda: evidence of a founder effect". J. Invest. Dermatol. 120 (6): 967–9. doi:10.1046/j.1523-1747.2003.12248.x. PMID 12787122.
• Chimienti F, Hogg RC, Plantard L, et al. (2004). "Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda". Hum. Mol. Genet. 12 (22): 3017–24. doi:10.1093/hmg/ddg320. PMID 14506129.
• Charfeddine C, Mokni M, Ben Mousli R, et al. (2004). "A novel missense mutation in the gene encoding SLURP-1 in patients with Mal de Meleda from northern Tunisia". Br. J. Dermatol. 149 (6): 1108–15. doi:10.1111/j.1365-2133.2003.05606.x. PMID 14674887.
• Mastrangeli R, Donini S, Kelton CA, et al. (2004). "ARS Component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda". European Journal of Dermatology. 13 (6): 560–70. PMID 14721776.
• Mokni M, Charfeddine C, Ben Mously R, et al. (2004). "Heterozygous manifestations in female carriers of Mal de Meleda". Clin. Genet. 65 (3): 244–6. doi:10.1111/j.0009-9163.2004.00224.x. PMID 14756676.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chao SC, Lai FJ, Yang MH, Lee JY (2006). "Mal de Meleda in a taiwanese". J. Formos. Med. Assoc. 104 (4): 276–8. PMID 15909066.
• Arredondo J, Chernyavsky AI, Webber RJ, Grando SA (2006). "Biological effects of SLURP-1 on human keratinocytes". J. Invest. Dermatol. 125 (6): 1236–41. doi:10.1111/j.0022-202X.2005.23973.x. PMID 16354194.
• Arredondo J, Chernyavsky AI, Grando SA (2007). "OVEREXPRESSION OF SLURP-1 AND -2 ALLEVIATES THE TUMORIGENIC ACTION OF TOBACCO-DERIVED NITROSAMINE ON IMMORTALIZED ORAL EPITHELIAL CELLS". Biochem. Pharmacol. 74 (8): 1315–9. doi:10.1016/j.bcp.2007.06.026. PMC 2046218. PMID 17643396.