SPACA3

SPACA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4YF2
Identifiers
Aliases	SPACA3, 1700025M08Rik, ALLP17, CT54, LYC3, LYZL3, SLLP1, LYZC, sperm acrosome associated 3
External IDs	MGI: 1922872 HomoloGene: 18365 GeneCards: SPACA3
Gene ontology Molecular function • protein binding • lysozyme activity Cellular component • integral component of membrane • extracellular region • lysosome • acrosomal vesicle • secretory granule • membrane • acrosomal membrane • cytoplasmic vesicle Biological process • monocyte activation • cell wall macromolecule catabolic process • fertilization • positive regulation of phagocytosis • response to virus • positive regulation of macrophage activation • sperm-egg recognition • defense response to Gram-positive bacterium • peptidoglycan catabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	124912	75622
Ensembl	ENSG00000141316	ENSMUSG00000053184
UniProt	Q8IXA5	Q9D9X8
RefSeq (mRNA)	NM_173847 NM_001317225 NM_001317226	NM_029367
RefSeq (protein)	NP_776246.1 NP_001304155.1	NP_083643.1
Location (UCSC)	Chr 17: 32.97 – 33 Mb	Chr 11: 80.86 – 80.87 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Sperm acrosome membrane-associated protein 3 is a protein that in humans is encoded by the SPACA3 gene. It may be involved in adhesion to the egg before the egg is fertilized.^[3][4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Mandal A, Klotz KL, Shetty J, Jayes FL, Wolkowicz MJ, Bolling LC, Coonrod SA, Black MB, Diekman AB, Haystead TA, Flickinger CJ, Herr JC (Apr 2003). "SLLP1, a unique, intra-acrosomal, non-bacteriolytic, c lysozyme-like protein of human spermatozoa". Biol Reprod. 68 (5): 1525–37. doi:10.1095/biolreprod.102.010108. PMID 12606493.
4. "Entrez Gene: SPACA3 sperm acrosome associated 3".

Further reading

• Niyonsaba F, Ogawa H (2006). "Protective roles of the skin against infection: implication of naturally occurring human antimicrobial agents beta-defensins, cathelicidin LL-37 and lysozyme.". J. Dermatol. Sci. 40 (3): 157–68. doi:10.1016/j.jdermsci.2005.07.009. PMID 16150577.
• Cramer EM, Breton-Gorius J (1987). "Ultrastructural localization of lysozyme in human neutrophils by immunogold.". J. Leukoc. Biol. 41 (3): 242–7. PMID 3470418.
• Welsh IR, Spitznagel JK (1973). "Distribution of lysosomal enzymes, cationic proteins, and bactericidal substances in subcellular fractions of human polymorphonuclear leukocytes.". Infect. Immun. 4 (2): 97–102. PMC 416271. PMID 5154881.
• Ibrahim HR, Matsuzaki T, Aoki T (2001). "Genetic evidence that antibacterial activity of lysozyme is independent of its catalytic function.". FEBS Lett. 506 (1): 27–32. doi:10.1016/S0014-5793(01)02872-1. PMID 11591365.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Wang Z, Zhang Y, Mandal A, et al. (2005). "The spermatozoa protein, SLLP1, is a novel cancer-testis antigen in hematologic malignancies.". Clin. Cancer Res. 10 (19): 6544–50. doi:10.1158/1078-0432.CCR-04-0911. PMID 15475442.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhang K, Gao R, Zhang H, et al. (2006). "Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family.". Biol. Reprod. 73 (5): 1064–71. doi:10.1095/biolreprod.105.041889. PMID 16014814.