SPC24

SPC24
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VE7, 3IZ0
Identifiers
Aliases	SPC24, SPBC24, NDC80 kinetochore complex component
External IDs	MGI: 1914879 HomoloGene: 12166 GeneCards: SPC24
Gene ontology Molecular function • protein binding Cellular component • condensed chromosome kinetochore • cytosol • Ndc80 complex • nucleolus • chromosome, centromeric region • nucleus • kinetochore • chromosome Biological process • cell division • cell cycle • mitotic nuclear division • sister chromatid cohesion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	147841	67629
Ensembl	ENSG00000161888	ENSMUSG00000074476
UniProt	Q8NBT2	Q9D083
RefSeq (mRNA)	NM_182513 NM_001317031 NM_001317032 NM_001317033	NM_026282
RefSeq (protein)	NP_872319.1 NP_001303960.1 NP_001303962.1	NP_080558.1
Location (UCSC)	Chr 19: 11.13 – 11.16 Mb	Chr 9: 21.76 – 21.76 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Kinetochore protein Spc24 is a protein that in humans is encoded by the SPC24 gene.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: SPC24 SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)".

Further reading

• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Ahonen LJ, Kallio MJ, Daum JR, et al. (2005). "Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores". Curr. Biol. 15 (12): 1078–89. doi:10.1016/j.cub.2005.05.026. PMID 15964272.
• Ciferri C, De Luca J, Monzani S, et al. (2005). "Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore". J. Biol. Chem. 280 (32): 29088–95. doi:10.1074/jbc.M504070200. PMID 15961401.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Cheeseman IM, Niessen S, Anderson S, et al. (2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes Dev. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
• McCleland ML, Kallio MJ, Barrett-Wilt GA, et al. (2004). "The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment". Curr. Biol. 14 (2): 131–7. doi:10.1016/j.cub.2003.12.058. PMID 14738735.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bharadwaj R; Qi W; Yu H (2004). "Identification of two novel components of the human NDC80 kinetochore complex". J. Biol. Chem. 279 (13): 13076–85. doi:10.1074/jbc.M310224200. PMID 14699129.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.