SSH2

SSH2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NT2
Identifiers
Aliases	SSH2, SSH-2, SSH-2L, slingshot protein phosphatase 2
External IDs	MGI: 2679255 HomoloGene: 14116 GeneCards: SSH2
Gene ontology Molecular function • protein tyrosine phosphatase activity • DNA binding • phosphatase activity • actin binding • phosphoprotein phosphatase activity • hydrolase activity • protein tyrosine/serine/threonine phosphatase activity Cellular component • cytoplasm • extracellular fluid • cytoskeleton Biological process • regulation of lamellipodium assembly • regulation of axonogenesis • regulation of actin polymerization or depolymerization • protein dephosphorylation • peptidyl-tyrosine dephosphorylation • actin cytoskeleton organization • dephosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	85464	237860
Ensembl	ENSG00000141298	ENSMUSG00000037926
UniProt	Q76I76	Q5SW75
RefSeq (mRNA)	NM_001282129 NM_001282130 NM_001282131 NM_033389	NM_001291190 NM_177710
RefSeq (protein)	NP_001269058.1 NP_001269059.1 NP_001269060.1 NP_203747.2	NP_001278119.1 NP_808378.2
Location (UCSC)	Chr 17: 29.63 – 29.93 Mb	Chr 11: 77.22 – 77.46 Mb
PubMed search	[1]	[2]
Wikidata

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For the SSH-2 protocol, see Secure Shell#Version 2.x

Protein phosphatase Slingshot homolog 2 is an enzyme that in humans is encoded by the SSH2 gene.^[3][4][5]

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (Feb 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell. 108 (2): 233–46. doi:10.1016/S0092-8674(01)00638-9. PMID 11832213.
4. Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
5. "Entrez Gene: SSH2 slingshot homolog 2 (Drosophila)".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chan SY, Chan AK, Cheung BP, et al. (2004). "Identification of genes expressed during myocardial development.". Chin. Med. J. 116 (9): 1329–32. PMID 14527359.
• Ohta Y, Kousaka K, Nagata-Ohashi K, et al. (2004). "Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin.". Genes Cells. 8 (10): 811–24. doi:10.1046/j.1365-2443.2003.00678.x. PMID 14531860.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Soosairajah J, Maiti S, Wiggan O, et al. (2005). "Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin.". EMBO J. 24 (3): 473–86. doi:10.1038/sj.emboj.7600543. PMC 548651. PMID 15660133.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Kligys K, Claiborne JN, DeBiase PJ, et al. (2007). "The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes.". J. Biol. Chem. 282 (44): 32520–8. doi:10.1074/jbc.M707041200. PMC 2754063. PMID 17848544.