STXBP5

STXBP5
Identifiers
Aliases	STXBP5, LGL3, LLGL3, Nbla04300, syntaxin binding protein 5
External IDs	MGI: 1926058 HomoloGene: 16402 GeneCards: STXBP5
Gene ontology Molecular function • GTPase activator activity • syntaxin-1 binding • Rab GTPase binding • syntaxin binding Cellular component • cytoplasm • integral component of membrane • acetylcholine-gated channel complex • membrane • synaptic vesicle • plasma membrane • synapse • secretory granule • cell junction • SNARE complex • cytoplasmic vesicle membrane • cytoplasmic vesicle Biological process • regulation of exocytosis • transport • regulation of gene expression • protein transport • positive regulation of exocytosis • regulation of blood coagulation • vesicle-mediated transport • exocytosis • regulation of protein secretion • positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	134957	78808
Ensembl	ENSG00000164506	ENSMUSG00000019790
UniProt	Q5T5C0	Q8K400
RefSeq (mRNA)	NM_001127715 NM_139244	NM_001081344 NM_030191
RefSeq (protein)	NP_001121187.1 NP_640337.3	XP_006512989.1
Location (UCSC)	Chr 6: 147.2 – 147.39 Mb	Chr 10: 9.76 – 9.9 Mb
PubMed search	[1]	[2]
Wikidata

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Syntaxin-binding protein 5 is a protein that in humans is encoded by the STXBP5 gene.^[3][4][5]

Function

Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced variants have been identified, but their biological validity has not been determined.^[5]

Interactions

STXBP5 has been shown to interact with STX4^[6] and STX1A.^[3][6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Fujita Y, Shirataki H, Sakisaka T, Asakura T, Ohya T, Kotani H, Yokoyama S, Nishioka H, Matsuura Y, Mizoguchi A, Scheller RH, Takai Y (Jun 1998). "Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process". Neuron. 20 (5): 905–15. doi:10.1016/S0896-6273(00)80472-9. PMID 9620695.
4. Katoh M, Katoh M (Feb 2004). "Identification and characterization of human LLGL4 gene and mouse Llgl4 gene in silico". Int. J. Oncol. 24 (3): 737–42. doi:10.3892/ijo.24.3.737. PMID 14767561.
5. "Entrez Gene: STXBP5 syntaxin binding protein 5 (tomosyn)".
6. Widberg CH, Bryant NJ, Girotti M, Rea S, James DE (Sep 2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". J. Biol. Chem. 278 (37): 35093–101. doi:10.1074/jbc.M304261200. PMID 12832401.

Further reading

• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Widberg CH, Bryant NJ, Girotti M, Rea S, James DE (2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". J. Biol. Chem. 278 (37): 35093–101. doi:10.1074/jbc.M304261200. PMID 12832401.
• Yokoyama S, Shirataki H, Sakisaka T, Takai Y (1999). "Three splicing variants of tomosyn and identification of their syntaxin-binding region". Biochem. Biophys. Res. Commun. 256 (1): 218–22. doi:10.1006/bbrc.1999.0300. PMID 10066450.