Setrobuvir

Setrobuvir
Names
IUPAC name
N-(3-{(4aR,5S,8R,8aS)-1-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2,4a,5,6,7,8,8a-octahydro-5,8-methanoquinolin-3-yl}-1,1-dioxo-1,4-dihydro-1λ6,2,4-benzothiadiazin-7-yl)methanesulfonamide
Other names
ANA-598; ANA598
Identifiers
1214735-09-7 N
1071517-39-9 YesY
3D model (Jmol) Interactive image
ChEMBL ChEMBL1076263 YesY
ChemSpider 24680206 YesY
KEGG D10165 N
PubChem 45136829
Properties
C25H25FN4O6S2
Molar mass 560.62 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Setrobuvir (INN,[1] USAN,[2] also known as ANA-598) was an experimental drug candidate for the treatment of hepatitis C. It was discovered at Anadys Pharmaceuticals. In 2011, Roche acquired Anadys in order to develop setrobuvir.[3] It was in Phase IIb clinical trials, used in combination with interferon and ribavirin,[4] targeting hepatitis C patients with genotype 1.[3]

Setrobuvir works by inhibiting the hepatitis C enzyme NS5B, an RNA polymerase.[5]

Its development was discontinued on July 15, 2015.[6]

References

  1. "International Nonproprietary Names for Pharmaceutical Substances (INN). RECOMMENDED International Nonproprietary Names: List 68" (PDF). World Health Organization. p. 322.
  2. Statement on a Nonproprietary Name Adopted by the USAN Council
  3. 1 2 "HCV Followup: Anadys Acquired for Active Antiviral". Central Science, Chemical & Engineering News. October 24, 2011.
  4. "Roche-Anadys Hookup Could Spark More Hep C Acquisitions". TheStreet.com. October 17, 2011.
  5. Ruebsam, F; Murphy, DE; Tran, CV; Li, LS; Zhao, J; Dragovich, PS; McGuire, HM; Xiang, AX; et al. (2009). "Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase". Bioorganic & Medicinal Chemistry Letters. 19 (22): 6404–12. doi:10.1016/j.bmcl.2009.09.045. PMID 19818610.
  6. "Setrobuvir — UKMi New Drugs Online Database". UKMi Medicines Information.


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