TAOK2

TAOK2
Identifiers
Aliases	TAOK2, MAP3K17, PSK, PSK1, PSK1-BETA, TAO1, TAO2, TAO kinase 2
External IDs	MGI: 1915919 HomoloGene: 74531 GeneCards: TAOK2
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • kinase activity • protein serine/threonine kinase activity • mitogen-activated protein kinase kinase binding • ATP binding • signal transducer, downstream of receptor, with serine/threonine kinase activity Cellular component • cytoplasm • integral component of membrane • cell projection • membrane • receptor complex • cytoplasmic, membrane-bounded vesicle • dendrite • nucleolus • cytoskeleton • cytoplasmic vesicle membrane • cytoplasmic vesicle • nucleus Biological process • phosphorylation • activation of MAPKK activity • protein targeting to membrane • response to stress • positive regulation of JNK cascade • G2 DNA damage checkpoint • cellular response to DNA damage stimulus • protein phosphorylation • focal adhesion assembly • stress-activated MAPK cascade • regulation of cell growth • regulation of cell shape • cell migration • actin cytoskeleton organization • positive regulation of stress-activated MAPK cascade • apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9344	381921
Ensembl	ENSG00000149930	ENSMUSG00000059981
UniProt	Q9UL54	Q6ZQ29
RefSeq (mRNA)	NM_001252043 NM_004783 NM_016151	NM_001163774 NM_001163775
RefSeq (protein)	NP_001238972.1 NP_004774.1 NP_057235.2	NP_001157246.1 NP_001157247.1
Location (UCSC)	Chr 16: 29.97 – 29.99 Mb	Chr 7: 126.87 – 126.88 Mb
PubMed search	[1]	[2]
Wikidata

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Serine/threonine-protein kinase TAO2 is an enzyme that in humans is encoded by the TAOK2 gene.^[3][4][5]

Interactions

TAOK2 has been shown to interact with MAP2K6^[6] and MAP2K3.^[6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485. Check date values in: |year= / |date= mismatch (help)
4. Hutchison M, Berman KS, Cobb MH (Dec 1998). "Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades". J. Biol. Chem. 273 (44): 28625–32. doi:10.1074/jbc.273.44.28625. PMID 9786855.
5. "Entrez Gene: TAOK2 TAO kinase 2".
6. Chen Z, Cobb MH (May 2001). "Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2". J. Biol. Chem. 276 (19): 16070–5. doi:10.1074/jbc.M100681200. PMID 11279118.

Further reading

• Chen Z, Hutchison M, Cobb MH (1999). "Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain". J. Biol. Chem. 274 (40): 28803–7. doi:10.1074/jbc.274.40.28803. PMID 10497253.
• Moore TM, Garg R, Johnson C, Coptcoat MJ, Ridley AJ, Morris JD (2000). "PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization". J. Biol. Chem. 275 (6): 4311–22. doi:10.1074/jbc.275.6.4311. PMID 10660600.
• Chen Z, Cobb MH (2001). "Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2". J. Biol. Chem. 276 (19): 16070–5. doi:10.1074/jbc.M100681200. PMID 11279118.
• Nakayama M, Kikuno R, Ohara O (2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Mitsopoulos C, Zihni C, Garg R, Ridley AJ, Morris JD (2003). "The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability". J. Biol. Chem. 278 (20): 18085–91. doi:10.1074/jbc.M213064200. PMID 12639963.
• Chen Z, Raman M, Chen L, Lee SF, Gilman AG, Cobb MH (2003). "TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors". J. Biol. Chem. 278 (25): 22278–83. doi:10.1074/jbc.M301173200. PMID 12665513.
• Yustein JT, Xia L, Kahlenburg JM, Robinson D, Templeton D, Kung HJ (2003). "Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38". Oncogene. 22 (40): 6129–41. doi:10.1038/sj.onc.1206605. PMID 13679851.
• Huangfu WC, Omori E, Akira S, Matsumoto K, Ninomiya-Tsuji J (2006). "Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways". J. Biol. Chem. 281 (39): 28802–10. doi:10.1074/jbc.M603627200. PMC 1797068. PMID 16893890.
• Zihni C, Mitsopoulos C, Tavares IA, Baum B, Ridley AJ, Morris JD (2007). "Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing". J. Biol. Chem. 282 (9): 6484–93. doi:10.1074/jbc.M608336200. PMID 17158878.