TAP1

TAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JJ7
Identifiers
Aliases	TAP1, ABC17, ABCB2, APT1, D6S114E, PSF-1, PSF1, RING4, TAP1*0102N, TAP1N, transporter 1, ATP-binding cassette, sub-family B (MDR/TAP), transporter 1, ATP binding cassette subfamily B member
External IDs	MGI: 98483 HomoloGene: 495 GeneCards: TAP1
Gene ontology Molecular function • MHC protein binding • ATPase activity, coupled to transmembrane movement of substances • nucleotide binding • protein homodimerization activity • peptide-transporting ATPase activity • peptide transporter activity • TAP2 binding • MHC class Ib protein binding • ATPase activity • protein binding • MHC class I protein binding • TAP1 binding • ATP binding • peptide antigen-transporting ATPase activity • peptide antigen binding • ADP binding Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • TAP complex • integral component of endoplasmic reticulum membrane • endoplasmic reticulum • mitochondrion • host cell Biological process • defense response • intracellular transport of viral protein in host cell • adaptive immune response • immune system process • antigen processing and presentation of peptide antigen via MHC class I • positive regulation of antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent • antigen processing and presentation of endogenous peptide antigen via MHC class I • transmembrane transport • transport • protein transport • peptide transport • viral process • antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent • cytosol to ER transport • antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6890	21354
Ensembl	n/a	ENSMUSG00000037321
UniProt	Q03518	P21958
RefSeq (mRNA)	NM_001292022 NM_000593	NM_001161730 NM_013683
RefSeq (protein)	NP_000584.2 NP_001278951.1	NP_038711.2
Location (UCSC)	Chr 6: 32.85 – 32.85 Mb	Chr 17: 34.19 – 34.2 Mb
PubMed search	[1]	[2]
Wikidata

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Transporter associated with Antigen Processing 1 is a protein that in humans is encoded by the TAP1 gene.^[3][4]

Function

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.^[5]

See also

• ATP-binding cassette transporter

Interactions

TAP1 has been shown to interact with:

• HLA-A,^[6] and
• Tapasin.^[6][7]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Bodmer JG, Marsh SG, Albert ED, Bodmer WF, Dupont B, Erlich HA, Mach B, Mayr WR, Parham P, Sasazuki T (Oct 1992). "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system". Tissue Antigens. 39 (4): 161–73. doi:10.1111/j.1399-0039.1992.tb01932.x. PMID 1529427.
4. Bahram S, Arnold D, Bresnahan M, Strominger JL, Spies T (Dec 1991). "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region". Proc Natl Acad Sci U S A. 88 (22): 10094–8. doi:10.1073/pnas.88.22.10094. PMC 52874. PMID 1946428.
5. "Entrez Gene: TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)".
6. Paulsson KM, Kleijmeer MJ, Griffith J, Jevon M, Chen S, Anderson PO, Sjogren HO, Li S, Wang P (May 2002). "Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum". J. Biol. Chem. 277 (21): 18266–71. doi:10.1074/jbc.M201388200. PMID 11884415.
7. Raghuraman G, Lapinski PE, Raghavan M (Nov 2002). "Tapasin interacts with the membrane-spanning domains of both TAP subunits and enhances the structural stability of TAP1 x TAP2 Complexes". J. Biol. Chem. 277 (44): 41786–94. doi:10.1074/jbc.M207128200. PMID 12213826.

Further reading

• Townsend A, Trowsdale J (1993). "The transporters associated with antigen presentation". Semin. Cell Biol. 4 (1): 53–61. doi:10.1006/scel.1993.1007. PMID 8453065.
• Schölz C, Tampé R (2006). "The intracellular antigen transport machinery TAP in adaptive immunity and virus escape mechanisms". J. Bioenerg. Biomembr. 37 (6): 509–15. doi:10.1007/s10863-005-9500-1. PMID 16691491.
• Beck S, Kelly A, Radley E, Khurshid F, Alderton RP, Trowsdale J (1992). "DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing". J. Mol. Biol. 228 (2): 433–41. doi:10.1016/0022-2836(92)90832-5. PMID 1453454.
• Colonna M, Bresnahan M, Bahram S, Strominger JL, Spies T (1992). "Allelic variants of the human putative peptide transporter involved in antigen processing". Proc. Natl. Acad. Sci. U.S.A. 89 (9): 3932–6. doi:10.1073/pnas.89.9.3932. PMC 525605. PMID 1570316.
• Trowsdale J, Hanson I, Mockridge I, Beck S, Townsend A, Kelly A (1991). "Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters". Nature. 348 (6303): 741–4. doi:10.1038/348741a0. PMID 2259383.
• Spies T, Bresnahan M, Bahram S, Arnold D, Blanck G, Mellins E, Pious D, DeMars R (1991). "A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway". Nature. 348 (6303): 744–7. doi:10.1038/348744a0. PMID 2259384.
• Cerundolo V, Alexander J, Anderson K, Lamb C, Cresswell P, McMichael A, Gotch F, Townsend A (1990). "Presentation of viral antigen controlled by a gene in the major histocompatibility complex". Nature. 345 (6274): 449–52. doi:10.1038/345449a0. PMID 2342577.
• Szafer F, Oksenberg JR, Steinman L (1994). "New allelic polymorphisms in TAP genes". Immunogenetics. 39 (5): 374. doi:10.1007/BF00189240. PMID 8168860.
• Jackson DG, Capra JD (1994). "TAP1 alleles in insulin-dependent diabetes mellitus: a newly defined centromeric boundary of disease susceptibility". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11079–83. doi:10.1073/pnas.90.23.11079. PMC 47925. PMID 8248212.
• Glynne R, Kerr LA, Mockridge I, Beck S, Kelly A, Trowsdale J (1993). "The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing". Eur. J. Immunol. 23 (4): 860–6. doi:10.1002/eji.1830230414. PMID 8458375.
• Beck S, Abdulla S, Alderton RP, Glynne RJ, Gut IG, Hosking LK, Jackson A, Kelly A, Newell WR, Sanseau P, Radley E, Thorpe KL, Trowsdale J (1996). "Evolutionary dynamics of non-coding sequences within the class II region of the human MHC". J. Mol. Biol. 255 (1): 1–13. doi:10.1006/jmbi.1996.0001. PMID 8568858.
• Chen HL, Gabrilovich D, Tampé R, Girgis KR, Nadaf S, Carbone DP (1996). "A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer". Nat. Genet. 13 (2): 210–3. doi:10.1038/ng0696-210. PMID 8640228.
• Ahn K, Meyer TH, Uebel S, Sempé P, Djaballah H, Yang Y, Peterson PA, Früh K, Tampé R (1996). "Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47". EMBO J. 15 (13): 3247–55. PMC 451885. PMID 8670825.
• Lewis JW, Neisig A, Neefjes J, Elliott T (1997). "Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP". Curr. Biol. 6 (7): 873–83. doi:10.1016/S0960-9822(02)00611-5. PMID 8805302.
• Nijenhuis M, Hämmerling GJ (1997). "Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site". J. Immunol. 157 (12): 5467–77. PMID 8955196.
• Gobin SJ, Wilson L, Keijsers V, Van den Elsen PJ (1997). "Antigen processing and presentation by human trophoblast-derived cell lines". J. Immunol. 158 (8): 3587–92. PMID 9103419.
• Ahn K, Gruhler A, Galocha B, Jones TR, Wiertz EJ, Ploegh HL, Peterson PA, Yang Y, Früh K (1997). "The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP". Immunity. 6 (5): 613–21. doi:10.1016/S1074-7613(00)80349-0. PMID 9175839.

External links

• TAP1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.