TDRD7

TDRD7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RCO
Identifiers
Aliases	TDRD7, CATC4, CTRCT36, PCTAIRE2BP, TRAP, tudor domain containing 7
External IDs	MGI: 2140279 HomoloGene: 8618 GeneCards: TDRD7
Gene ontology Molecular function • mRNA binding • protein binding • protein N-terminus binding • RNA binding Cellular component • cytoplasm • chromatoid body • mitochondrial matrix • ribonucleoprotein granule Biological process • posttranscriptional regulation of gene expression • cell differentiation • lens fiber cell differentiation • lens morphogenesis in camera-type eye • spermatogenesis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23424	100121
Ensembl	ENSG00000196116	ENSMUSG00000035517
UniProt	Q8NHU6	Q8K1H1
RefSeq (mRNA)	NM_001302884 NM_014290	NM_001290475 NM_146142
RefSeq (protein)	NP_001289813.1 NP_055105.2	NP_001277404.1 NP_666254.1
Location (UCSC)	Chr 9: 97.41 – 97.5 Mb	Chr 4: 45.97 – 46.03 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Tudor domain-containing protein 7 is a protein that in humans is encoded by the TDRD7 gene.^[3][4]

In melanocytic cells TDRD7 gene expression may be regulated by MITF.^[5]

Gene polymorphism

Various single nucleotide polymorphisms (SNPs) of the TDRD7 gene have been identified and for some of them an association with lower susceptibility to age-related cataract was shown.^[6]

Interactions

TDRD7 has been shown to interact with TACC1.^[7]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
4. "Entrez Gene: TDRD7 tudor domain containing 7".
5. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
6. Zheng C, Wu M, He CY, An XJ, Sun M, Chen CL, Ye J (Feb 2014). "RNA granule component TDRD7 gene polymorphisms in a Han Chinese population with age-related cataract". J. Int. Med. Res. 42 (1): 153–63. doi:10.1177/0300060513504702. PMID 24435515.
7. Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (Nov 2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251.

Further reading

• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251.
• Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH (2002). "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells". Biochem. J. 363 (Pt 1): 195–200. doi:10.1042/0264-6021:3630195. PMC 1222467. PMID 11903063.
• Yamochi T, Nishimoto I, Okuda T, Matsuoka M (2001). "ik3-1/Cables is associated with Trap and Pctaire2". Biochem. Biophys. Res. Commun. 286 (5): 1045–50. doi:10.1006/bbrc.2001.5493. PMID 11527406.
• Hirose T, Kawabuchi M, Tamaru T, Okumura N, Nagai K, Okada M (2000). "Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain". Eur. J. Biochem. 267 (7): 2113–21. doi:10.1046/j.1432-1327.2000.01218.x. PMID 10727952.