TESK2

TESK2
Identifiers
Aliases	TESK2
External IDs	MGI: 2385204 HomoloGene: 5188 GeneCards: TESK2
Gene ontology Molecular function • transferase activity • protein kinase activity • protein serine/threonine/tyrosine kinase activity • protein serine/threonine kinase activity • protein tyrosine kinase activity • nucleotide binding • protein binding • ATP binding • metal ion binding • kinase activity Cellular component • cytoplasm • nucleus • nucleoplasm Biological process • protein phosphorylation • peptidyl-tyrosine phosphorylation • focal adhesion assembly • actin cytoskeleton organization • spermatogenesis • phosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10420	230661
Ensembl	ENSG00000070759	ENSMUSG00000033985
UniProt	Q96S53	Q8VCT9
RefSeq (mRNA)	NM_007170 NM_001320800	NM_146151
RefSeq (protein)	NP_009101.2 NP_001307729.1	NP_666263.3
Location (UCSC)	Chr 1: 45.34 – 45.49 Mb	Chr 4: 116.72 – 116.81 Mb
PubMed search	[1]	[2]
Wikidata

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Dual specificity testis-specific protein kinase 2 is an enzyme that in humans is encoded by the TESK2 gene.^[3][4]

Function

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meiotic stages and/or early stages of spermiogenesis.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Røsok O, Pedeutour F, Ree AH, Aasheim HC (October 1999). "Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis". Genomics. 61 (1): 44–54. doi:10.1006/geno.1999.5922. PMID 10512679.
4. "Entrez Gene: TESK2 testis-specific kinase 2".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Toshima JY, Toshima J, Watanabe T, Mizuno K (November 2001). "Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1". The Journal of Biological Chemistry. 276 (46): 43471–81. doi:10.1074/jbc.M104620200. PMID 11555644.
• Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K (August 2001). "Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells". The Journal of Biological Chemistry. 276 (33): 31449–58. doi:10.1074/jbc.M102988200. PMID 11418599.