TMEM49

VMP1
Identifiers
Aliases	VMP1, EPG3, TANGO5, TMEM49, vacuole membrane protein 1
External IDs	MGI: 1923159 HomoloGene: 23686 GeneCards: VMP1
Gene ontology Molecular function • protein binding Cellular component • vacuolar membrane • integral component of membrane • vacuole • plasma membrane • autophagosome membrane • nucleolus • endoplasmic reticulum • membrane • pre-autophagosomal structure • endoplasmic reticulum-Golgi intermediate compartment membrane Biological process • autophagy • single organismal cell-cell adhesion • cell adhesion • regulation of autophagy • Golgi organization • embryo implantation • endoplasmic reticulum organization • exocytosis • cell junction assembly Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	81671	75909
Ensembl	ENSG00000062716	ENSMUSG00000018171
UniProt	Q96GC9	Q99KU0
RefSeq (mRNA)	NM_030938	NM_029478
RefSeq (protein)	NP_112200.2	NP_083754.2
Location (UCSC)	Chr 17: 59.71 – 59.84 Mb	Chr 11: 86.58 – 86.68 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Transmembrane protein 49 is a protein that in humans is encoded by the TMEM49 gene.^[3][4][5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
4. Dusetti NJ, Jiang Y, Vaccaro MI, Tomasini R, Azizi Samir A, Calvo EL, Ropolo A, Fiedler F, Mallo GV, Dagorn JC, Iovanna JL (Jan 2002). "Cloning and expression of the rat vacuole membrane protein 1 (VMP1), a new gene activated in pancreas with acute pancreatitis, which promotes vacuole formation". Biochem Biophys Res Commun. 290 (2): 641–9. doi:10.1006/bbrc.2001.6244. PMID 11785947.
5. "Entrez Gene: TMEM49 transmembrane protein 49".

Further reading

• Ropolo A, Grasso D, Pardo R, et al. (2008). "The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells.". J. Biol. Chem. 282 (51): 37124–33. doi:10.1074/jbc.M706956200. PMID 17940279.
• Sauermann M, Sahin O, Sültmann H, et al. (2008). "Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells.". Oncogene. 27 (9): 1320–6. doi:10.1038/sj.onc.1210743. PMID 17724469.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Starkuviene V, Liebel U, Simpson JC, et al. (2004). "High-content screening microscopy identifies novel proteins with a putative role in secretory membrane traffic.". Genome Res. 14 (10A): 1948–56. doi:10.1101/gr.2658304. PMC 524419. PMID 15466293.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.