TNKS1BP1

TNKS1BP1
Identifiers
Aliases	TNKS1BP1, TAB182, tankyrase 1 binding protein 1
External IDs	MGI: 2446193 HomoloGene: 14117 GeneCards: TNKS1BP1
Gene ontology Molecular function • enzyme binding • ankyrin binding • cadherin binding involved in cell-cell adhesion Cellular component • cytoplasm • chromosome • CCR4-NOT complex • cytosol • plasma membrane • nuclear telomeric heterochromatin • cytoskeleton • nucleus • nucleoplasm • cell-cell adherens junction Biological process • nuclear-transcribed mRNA poly(A) tail shortening • telomere maintenance via telomerase • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • cell-cell adhesion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	85456	228140
Ensembl	ENSG00000149115	ENSMUSG00000033955
UniProt	Q9C0C2	P58871
RefSeq (mRNA)	NM_033396	NM_001081260
RefSeq (protein)	NP_203754.2	NP_001074729.1
Location (UCSC)	Chr 11: 57.3 – 57.32 Mb	Chr 2: 85.05 – 85.07 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

182 kDa tankyrase-1-binding protein is an enzyme that in humans is encoded by the TNKS1BP1 gene.^[3][4]

Interactions

TNKS1BP1 has been shown to interact with TNKS.^[3][5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Seimiya H, Smith S (Apr 2002). "The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)". J Biol Chem. 277 (16): 14116–26. doi:10.1074/jbc.M112266200. PMID 11854288.
4. "Entrez Gene: TNKS1BP1 tankyrase 1 binding protein 1, 182kDa".
5. Sbodio JI, Chi NW (Aug 2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner". J. Biol. Chem. 277 (35): 31887–92. doi:10.1074/jbc.M203916200. PMID 12080061.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
• Sbodio JI, Chi NW (2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner.". J. Biol. Chem. 277 (35): 31887–92. doi:10.1074/jbc.M203916200. PMID 12080061.
• Jikuya H, Takano J, Kikuno R, Hirosawa M, Nagase T, Nomura N, Ohara O (2003). "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.". DNA Res. 10 (1): 49–57. doi:10.1093/dnares/10.1.49. PMID 12693554.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Seimiya H, Muramatsu Y, Ohishi T, Tsuruo T (2005). "Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics.". Cancer Cell. 7 (1): 25–37. doi:10.1016/j.ccr.2004.11.021. PMID 15652747.
• Chang P, Coughlin M, Mitchison TJ (2006). "Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function.". Nat. Cell Biol. 7 (11): 1133–9. doi:10.1038/ncb1322. PMID 16244666.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Gelmini S, Quattrone S, Malentacchi F, Villari D, Travaglini F, Giannarini G, Della Melina A, Pazzagli M, Nicita G, Selli C, Orlando C (2007). "Tankyrase-1 mRNA expression in bladder cancer and paired urine sediment: preliminary experience.". Clin. Chem. Lab. Med. 45 (7): 862–6. doi:10.1515/CCLM.2007.133. PMID 17617028.