TXNDC12

TXNDC12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SEN, 2K8V
Identifiers
Aliases	TXNDC12, AG1, AGR1, ERP16, ERP18, ERP19, PDIA16, TLP19, hAG-1, hTLP19, thioredoxin domain containing 12
External IDs	MGI: 1913323 HomoloGene: 41074 GeneCards: TXNDC12
Gene ontology Molecular function • oxidoreductase activity • protein-disulfide reductase (glutathione) activity • peptide disulfide oxidoreductase activity • protein binding Cellular component • endoplasmic reticulum lumen • endoplasmic reticulum Biological process • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • oxidation-reduction process • cell redox homeostasis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51060	66073
Ensembl	ENSG00000117862	ENSMUSG00000028567
UniProt	O95881	Q9CQU0
RefSeq (mRNA)	NM_015913	NM_025334
RefSeq (protein)	NP_056997.1	NP_079610.1
Location (UCSC)	Chr 1: 52.02 – 52.06 Mb	Chr 4: 108.83 – 108.86 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Thioredoxin domain-containing protein 12 is a protein that in humans is encoded by the TXNDC12 gene.^[3][4][5]

TXNDC12 belongs to the thioredoxin superfamily (see TXN; MIM 187700). Members of this superfamily possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defense against oxidative stress, refolding of disulfide-containing proteins, and regulation of transcription factors^[6] (Liu et al., 2003).[supplied by OMIM]^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
4. Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
5. "Entrez Gene: TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum)".
6. Galligan JJ, Petersen DR (July 2012). "The human protein disulfide isomerase gene family". Human Genomics. 6 (6). doi:10.1186/1479-7364-6-6. PMC 3500226. PMID 23245351.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Alanen HI, Williamson RA, Howard MJ, et al. (2003). "Functional characterization of ERp18, a new endoplasmic reticulum-located thioredoxin superfamily member.". J. Biol. Chem. 278 (31): 28912–20. doi:10.1074/jbc.M304598200. PMID 12761212.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Liu F, Rong YP, Zeng LC, et al. (2004). "Isolation and characterization of a novel human thioredoxin-like gene hTLP19 encoding a secretory protein.". Gene. 315: 71–8. doi:10.1016/S0378-1119(03)00732-7. PMID 14557066.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.