TXNL4A

TXNL4A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PQN, 1QGV, 1SYX, 4BWQ, 4BWS, 4CDO, 3JCR
Identifiers
Aliases	TXNL4A, DIB1, DIM1, HsT161, SNRNP15, TXNL4, U5-15kD, BMKS, thioredoxin like 4A
External IDs	MGI: 1351613 HomoloGene: 7150 GeneCards: TXNL4A
Gene ontology Molecular function • protein binding Cellular component • U5 snRNP • U4/U6 x U5 tri-snRNP complex • spliceosomal complex • nucleus • nucleoplasm Biological process • RNA splicing, via transesterification reactions • mRNA splicing, via spliceosome • cell cycle • mRNA processing • spliceosomal complex assembly • mitotic nuclear division • cell division • RNA splicing Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10907	27366
Ensembl	ENSG00000141759	ENSMUSG00000057130
UniProt	P83876	P83877
RefSeq (mRNA)	NM_001303471 NM_001305557 NM_001305563 NM_001305564 NM_006701	NM_001038608 NM_001042408 NM_001042409 NM_025299 NM_178604
RefSeq (protein)	NP_001290400.1 NP_001292486.1 NP_001292492.1 NP_001292493.1 NP_006692.1	NP_079575.1
Location (UCSC)	Chr 18: 79.97 – 80.03 Mb	Chr 18: 80.21 – 80.22 Mb
PubMed search	[1]	[2]
Wikidata

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Thioredoxin-like protein 4A is a protein that in humans is encoded by the TXNL4A gene.^[3][4]

Interactions

TXNL4A has been shown to interact with PQBP1.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Zhang YZ, Gould KL, Dunbrack RL JR, Cheng H, Roder H, Golemis EA (October 2000). "The evolutionarily conserved Dim1 protein defines a novel branch of the thioredoxin fold superfamily". Physiol Genomics. 1 (3): 109–18. PMID 11015569.
4. "Entrez Gene: TXNL4A thioredoxin-like 4A".
5. Zhang Y, Lindblom T, Chang A, Sudol M, Sluder AE, Golemis EA (October 2000). "Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1". Gene. 257 (1): 33–43. doi:10.1016/S0378-1119(00)00372-3. PMID 11054566.

Further reading

• Reuter K, Nottrott S, Fabrizio P, Lührmann R, Ficner R (2000). "Identification, characterization and crystal structure analysis of the human spliceosomal U5 snRNP-specific 15 kD protein.". J. Mol. Biol. 294 (2): 515–25. doi:10.1006/jmbi.1999.3258. PMID 10610776.
• Zhang Y, Lindblom T, Chang A, Sudol M, Sluder AE, Golemis EA (2001). "Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1.". Gene. 257 (1): 33–43. doi:10.1016/S0378-1119(00)00372-3. PMID 11054566.
• Zhang YZ, Cheng H, Gould KL, Golemis EA, Roder H (2003). "Structure, stability, and function of hDim1 investigated by NMR, circular dichroism, and mutational analysis.". Biochemistry. 42 (32): 9609–18. doi:10.1021/bi034486i. PMID 12911302.
• Laggerbauer B, Liu S, Makarov E, Vornlocher HP, Makarova O, Ingelfinger D, Achsel T, Lührmann R (2005). "The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation.". RNA. 11 (5): 598–608. doi:10.1261/rna.2300805. PMC 1370748. PMID 15840814.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Jin T, Guo F, Wang Y, Zhang YZ (2007). "Identification of human dim1 as a peptidase with autocleavage activity.". Chemical biology & drug design. 68 (5): 266–72. doi:10.1111/j.1747-0285.2006.00447.x. PMID 17177886.