Tasuku Honjo
| Tasuku Honjo | |
|---|---|
 Tasuku Honjo | |
| Native name | 本庶 佑 |
| Born |
January 27, 1942 Kyoto, Japan |
| Nationality | Japanese |
| Fields | Molecular Immunology |
| Institutions | Kyoto University |
| Alma mater | Kyoto University |
| Doctoral advisor |
Yasutomi Nishizuka Osamu Hayaishi |
| Known for |
Class switch recombination Interleukin 5 Interleukin 4 |
| Notable awards |
Order of Culture (2013) Robert Koch Prize (2012) Imperial Prize of the Japan Academy (1996) Asahi Prize (1981) Tang Prize(2014)[1] Kyoto Prize(2016) William B. Coley Award (2016) |
Tasuku Honjo (本庶 佑 Honjo Tasuku, born January 27, 1942 in Kyoto) is a Japanese immunologist, best known for his discovery of Activation-induced Cytidine Deaminase that is essential for class switch recombination and somatic hypermutation.[2] He is also known for his molecular identification of cytokines: IL-4 and IL-5,[3] as well as the identification of Programmed cell death protein 1.[4]
Biography
Honjo completed his M.D. in 1966 from the Faculty of Medicine, Kyoto University, where in 1975 he received his doctorate in Medical Chemistry under the supervision of Yasutomi Nishizuka and Osamu Hayaishi.[5] Since 1982 he has been Professor and Chairman of the Department of Medical Chemistry, Kyoto University Graduate School of Medicine.[5]
Contribution
Honjo has established the basic conceptual framework of class switch recombination.[2] He presented a model explaining antibody gene rearrangement in class switch and, between 1980 and 1982, verified its validity by elucidating its DNA structure.[6] He succeeded in cDNA clonings of IL-4[7] and IL-5[8] cytokines involved in class switching and IL-2 receptor alpha chain in 1986, and went on further to discover Activation-induced Cytidine Deaminase[9] in 2000, demonstrating its importance in class switch recombination and somatic hypermutation.
Recognition
Honjo received many awards and honours including, the Order of Culture (2013), the Robert Koch Prize (2012), and the Imperial Prize of the Japan Academy (1996). He was elected as a foreign associate of the National Academy of Sciences, USA (2001), as a member of German Academy of Natural Scientists Leopoldina (2003), and also as a member of the Japan Academy (2005).
In 2014, Tasuku Honjo shared the inaugural Tang Prize in Biopharmaceutical Science with James Allison.[10] In 2016 he received the Kyoto Prize in Life Sciences.[11]
References
- ↑ Tang Prize 2014
- 1 2 Robert Koch Foundation confers award on Professors Honjo and Wimmer
- ↑ Kumanogoh, A; Ogata, M (2010). "The study of cytokines by Japanese researchers: A historical perspective". International Immunology. 22 (5): 341–5. doi:10.1093/intimm/dxq022. PMID 20338911.
- ↑ Ishida, Y; Agata, Y; Shibahara, K; Honjo, T (1992). "Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death". The EMBO Journal. 11 (11): 3887–95. PMC 556898
. PMID 1396582. - 1 2 "免疫のしくみに魅せられて－何ごとにも主体的に挑む" Biography of Tasuku Honjo (Japanese)
- ↑ Shimizu, A; Takahashi, N; Yaoita, Y; Honjo, T (1982). "Organization of the constant-region gene family of the mouse immunoglobulin heavy chain". Cell. 28 (3): 499–506. doi:10.1016/0092-8674(82)90204-5. PMID 6804095.
- ↑ Noma, Y; Sideras, P; Naito, T; Bergstedt-Lindquist, S; Azuma, C; Severinson, E; Tanabe, T; Kinashi, T; Matsuda, F; Yaoita, Y; Honjo, Tasuku (1986). "Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter". Nature. 319 (6055): 640–6. doi:10.1038/319640a0. PMID 3005865.
- ↑ Kinashi, T; Harada, N; Severinson, E; Tanabe, T; Sideras, P; Konishi, M; Azuma, C; Tominaga, A; Bergstedt-Lindqvist, S; Takahashi, M; Matsuda, Fumihiko; Yaoita, Yoshio; Takatsu, Kiyoshi; Honjo, Tasuku (1986). "Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II". Nature. 324 (6092): 70–3. doi:10.1038/324070a0. PMID 3024009.
- ↑ Muramatsu, M; Kinoshita, K; Fagarasan, S; Yamada, S; Shinkai, Y; Honjo, T (2000). "Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme". Cell. 102 (5): 553–63. doi:10.1016/s0092-8674(00)00078-7. PMID 11007474.
- ↑ "2014 Tang Prize in Biopharmaceutical Science".
- ↑ Kyoto Prize 2016