Thioesterase

Thioesterases are enzymes which belong to the esterase family. Esterases, in turn, are one type of the several hydrolases known.

Thioesterases exhibit Esterase activity (splitting of an ester into acid and alcohol, in the presence of water) specifically at a thiol group.

Thioesterases or thiolester hydrolases are identified as members of E.C.3.1.2.

Examples

Ubiquitin thiolesterase is a well-known example, whose structure has been analyzed.

Humans genes which encode thiolesterases include:^[1]

ACOT1, ACOT2, ACOT4, ACOT6, ACOT7, ACOT8, ACOT9, ACOT11 (STARD14), ACOT12 (STARD15), OLAH, PPT1, PPT2, THEM2 (ACOT13), THEM4, THEM4P1, THEM5

thioesterase I at the US National Library of Medicine Medical Subject Headings (MeSH)
thioesterase II at the US National Library of Medicine Medical Subject Headings (MeSH)

Thioesterases (EC 3.1.2)

Acetyl-CoA thioesterases

Acyl-CoA thioesterases	ACOT1 ACOT2 ACOT4 ACOT6 ACOT7 ACOT8 ACOT9 ACOT11 ACOT12 ACOT13

Formyl-CoA thioesterases

Palmitoyl protein thioesterases	PPT1 PPT2

Succinyl-CoA thioesterases

Ubiquitin C-terminal hydrolases	UCHL1 UCHL3 UCHL5

3.1.1: Carboxylic
ester hydrolases

Endodeoxyribonuclease	Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme UvrABC endonuclease

Endoribonuclease	RNase III RNase H 1 2A 2B 2C RNase P RNase A 1 2 3 4/5 RNase T1 RNA-induced silencing complex

either deoxy- or ribo-	Aspergillus nuclease S1 Micrococcal nuclease

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