Inositol-phosphate phosphatase

inositol-1(or 4)-monophosphatase
Inositol monophosphatase 2, dimer, Human
Identifiers
EC number	3.1.3.25
CAS number	37184-63-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, an inositol-phosphate phosphatase (EC 3.1.3.25) is an enzyme that catalyzes the chemical reaction

myo-inositol phosphate + H₂O $\rightleftharpoons$ myo-inositol + phosphate

Thus, the two substrates of this enzyme are myo-inositol phosphate and H₂O, whereas its two products are myo-inositol and phosphate.

This enzyme participates in 3 metabolic pathways: streptomycin biosynthesis, inositol phosphate metabolism, and phosphatidylinositol signaling system.

Nomenclature

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is myo-inositol-phosphate phosphohydrolase. Other names in common use include:

• myo-inositol-1(or 4)-monophosphatase,
• inositol 1-phosphatase,
• L-myo-inositol-1-phosphate phosphatase,
• myo-inositol 1-phosphatase,
• inositol phosphatase,
• inositol monophosphate phosphatase,
• inositol-1(or 4)-monophosphatase,
• myo-inositol-1(or 4)-phosphate phosphohydrolase,
• myo-inositol monophosphatase, and
• myo-inositol-1-phosphatase.

References

• Eisenberg F Jr (1967). "D-myoinositol 1-phosphate as product of cyclization of glucose 6-phosphate and substrate for a specific phosphatase in rat testis". J. Biol. Chem. 242 (7): 1375–82. PMID 4290245.
• Shute JK; Ragan, CI; Watling, KJ; Aspley, S; Jackson, RG; Reid, GG; Gani, D; Shute, JK (1988). "The purification and properties of myo-inositol monophosphatase from bovine brain". Biochem. J. 249 (3): 883–9. PMC 1148789. PMID 2833231.
• Hallcher LM, Sherman WR (1980). "The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain". J. Biol. Chem. 255 (22): 10896–901. PMID 6253491.
• Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD (1997). "A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder". Mol. Psychiatry. 2 (5): 393–7. doi:10.1038/sj.mp.4000325. PMID 9322233.
• Cockcroft, S. (Ed.), Biology of Phosphoinositides, Biology of Phosphoinositides, Oxford, 2000, p. 320-338.
• Ackermann KE, Gish BG, Honchar MP, Sherman WR (1987). "Evidence that inositol 1-phosphate in brain of lithium-treated rats results mainly from phosphatidylinositol metabolism". Biochem. J. 242 (2): 517–24. PMC 1147736. PMID 3036092.