UIMC1

UIMC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MKF, 2MKG, 2RR9, 2N9E
Identifiers
Aliases	UIMC1, RAP80, X2HRIP110, ubiquitin interaction motif containing 1
External IDs	MGI: 103185 HomoloGene: 9455 GeneCards: UIMC1
Gene ontology Molecular function • histone binding • K63-linked polyubiquitin binding • protein binding Cellular component • BRCA1-A complex • nucleus • nucleoplasm Biological process • response to ionizing radiation • positive regulation of DNA repair • histone H2A K63-linked deubiquitination • negative regulation of transcription, DNA-templated • double-strand break repair via nonhomologous end joining • regulation of transcription, DNA-templated • G2 DNA damage checkpoint • transcription, DNA-templated • cellular response to DNA damage stimulus • covalent chromatin modification • double-strand break repair • DNA repair Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51720	20184
Ensembl	ENSG00000087206	ENSMUSG00000025878
UniProt	Q96RL1	Q5U5Q9
RefSeq (mRNA)	NM_001199297 NM_001199298 NM_016290 NM_001317961	NM_001293660 NM_011307
RefSeq (protein)	NP_001186226.1 NP_001186227.1 NP_057374.3 NP_001304890.1	NP_001280589.1 NP_035437.1
Location (UCSC)	Chr 5: 176.91 – 177.02 Mb	Chr 13: 55.03 – 55.1 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

BRCA1-A complex subunit RAP80 is a protein that in humans is encoded by the UIMC1 gene.^[3][4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Yan Z, Kim YS, Jetten AM (Aug 2002). "RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor". J Biol Chem. 277 (35): 32379–88. doi:10.1074/jbc.M203475200. PMID 12080054.
4. "Entrez Gene: UIMC1 ubiquitin interaction motif containing 1".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kim YS, Nakanishi G, Oudes AJ, et al. (2004). "Tsp57: a novel gene induced during a specific stage of spermatogenesis.". Biol. Reprod. 70 (1): 106–13. doi:10.1095/biolreprod.103.018465. PMID 12954732.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Wang B, Matsuoka S, Ballif BA, et al. (2007). "Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.". Science. 316 (5828): 1194–8. doi:10.1126/science.1139476. PMC 3573690. PMID 17525340.
• Sobhian B, Shao G, Lilli DR, et al. (2007). "RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites.". Science. 316 (5828): 1198–202. doi:10.1126/science.1139516. PMC 2706583. PMID 17525341.
• Kim H, Chen J, Yu X (2007). "Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response.". Science. 316 (5828): 1202–5. doi:10.1126/science.1139621. PMID 17525342.
• Shebzukhov YV, Koroleva EP, Khlgatian SV, et al. (2007). "RAP80/UIMC1 as cancer-associated antigen: alternative splice variants and their immunogenicity.". Cancer Lett. 255 (2): 255–62. doi:10.1016/j.canlet.2007.04.013. PMID 17562356.
• Yan J, Kim YS, Yang XP, et al. (2007). "The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response.". Cancer Res. 67 (14): 6647–56. doi:10.1158/0008-5472.CAN-07-0924. PMC 2391092. PMID 17621610.
• Yan J, Yang XP, Kim YS, et al. (2007). "RAP80 interacts with the SUMO-conjugating enzyme UBC9 and is a novel target for sumoylation.". Biochem. Biophys. Res. Commun. 362 (1): 132–8. doi:10.1016/j.bbrc.2007.07.158. PMC 2049087. PMID 17698038.