AGGF1

AGGF1
Identifiers
Aliases	AGGF1, GPATC7, GPATCH7, HSU84971, HUS84971, VG5Q, angiogenic factor with G-patch and FHA domains 1
External IDs	MGI: 1913799 HomoloGene: 41220 GeneCards: AGGF1
Gene ontology Molecular function • protein binding • nucleic acid binding • RNA binding Cellular component • cytoplasm • perinuclear region of cytoplasm • extracellular region • nuclear speck • precatalytic spliceosome Biological process • vasculogenesis • multicellular organism development • cell differentiation • RNA processing • cell adhesion • positive regulation of endothelial cell proliferation • angiogenesis • positive regulation of angiogenesis • regulation of RNA splicing • mRNA processing Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55109	66549
Ensembl	ENSG00000164252	ENSMUSG00000021681
UniProt	Q8N302	Q7TN31
RefSeq (mRNA)	NM_018046	NM_025630
RefSeq (protein)	NP_060516.2	NP_079906.2
Location (UCSC)	Chr 5: 77.03 – 77.07 Mb	Chr 13: 95.35 – 95.38 Mb
PubMed search	[1]	[2]
Wikidata

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Angiogenic factor with G patch and FHA domains 1 is a protein that in humans is encoded by the AGGF1 gene.^[3][4][5][6]

The VG5Q gene encodes a potent angiogenic factor that contains a forkhead-associated domain and a G-patch domain.[supplied by OMIM]^[6]

See also

• Klippel-Trenaunay-Weber syndrome

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
4. Hu Y, Li L, Seidelmann SB, Timur AA, Shen PH, Driscoll DJ, Wang QK (Oct 2008). "Identification of association of common AGGF1 variants with susceptibility for Klippel-Trenaunay syndrome using the structure association program". Ann Hum Genet. 72 (Pt 5): 636–43. doi:10.1111/j.1469-1809.2008.00458.x. PMC 2602961. PMID 18564129.
5. Gutierrez S, Magano L, Delicado A, Mori MA, de Torres ML, Fernandez L, Palomares M, Fernandez E, Tarduchy GR, Molano J, Gracia R, Pajares IL, Lapunzina P (Nov 2006). "The G397A (E133K) change in the AGGF1 (VG5Q) gene is a single nucleotide polymorphism in the Spanish population". Am J Med Genet A. 140 (24): 2832–3. doi:10.1002/ajmg.a.31532. PMID 17103452.
6. "Entrez Gene: AGGF1 angiogenic factor with G patch and FHA domains 1".

External links

• Human AGGF1 genome location and AGGF1 gene details page in the UCSC Genome Browser.

Further reading

• Timur AA, Driscoll DJ, Wang Q (2005). "Biomedicine and diseases: the Klippel-Trenaunay syndrome, vascular anomalies and vascular morphogenesis". Cell. Mol. Life Sci. 62 (13): 1434–47. doi:10.1007/s00018-005-4523-7. PMC 1579804. PMID 15905966.
• Kihiczak GG, Meine JG, Schwartz RA, Janniger CK (2007). "Klippel-Trenaunay syndrome: a multisystem disorder possibly resulting from a pathogenic gene for vascular and tissue overgrowth". Int. J. Dermatol. 45 (8): 883–90. doi:10.1111/j.1365-4632.2006.02940.x. PMID 16911369.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Tian XL, Kadaba R, You SA, et al. (2004). "Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome". Nature. 427 (6975): 640–5. doi:10.1038/nature02320. PMC 1618873. PMID 14961121.
• Callebaut I, Mornon JP (2005). "OCRE: a novel domain made of imperfect, aromatic-rich octamer repeats". Bioinformatics. 21 (6): 699–702. doi:10.1093/bioinformatics/bti065. PMID 15486042.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Barker KT, Foulkes WD, Schwartz CE, et al. (2006). "Is the E133K allele of VG5Q associated with Klippel-Trenaunay and other overgrowth syndromes?". J. Med. Genet. 43 (7): 613–4. doi:10.1136/jmg.2006.040790. PMC 2564558. PMID 16443853.