VPS28

VPS28
Identifiers
Aliases	VPS28
External IDs	MGI: 1914164 HomoloGene: 69205 GeneCards: VPS28
Gene ontology Molecular function • protein complex binding • ubiquitin binding • protein binding Cellular component • cytoplasm • cytosol • endosome • membrane • late endosome membrane • plasma membrane • early endosome • endosome membrane • extracellular exosome • ESCRT I complex Biological process • intracellular transport of virus • positive regulation of ubiquitin-dependent endocytosis • positive regulation of protein catabolic process • viral budding via host ESCRT complex • viral life cycle • multivesicular body assembly • autophagy • endosomal transport • negative regulation of protein ubiquitination • transport • protein transport • ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway • protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51160	66914
Ensembl	ENSG00000160948	ENSMUSG00000059323
UniProt	Q9UK41 Q548N1	Q9D1C8
RefSeq (mRNA)	NM_016208 NM_183057	NM_025842 NM_001305668
RefSeq (protein)	NP_057292.1 NP_898880.1 NP_057292.1	NP_001292597.1 NP_080118.1
Location (UCSC)	Chr 8: 144.42 – 144.43 Mb	Chr 15: 76.62 – 76.64 Mb
PubMed search	[1]	[2]
Wikidata

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Vacuolar protein sorting-associated protein 28 homolog is a protein that in humans is encoded by the VPS28 gene.^[3]

Function

This gene encodes a protein involved in endosomal sorting of cell surface receptors via a multivesicular body/late endosome pathway. The encoded protein is one of the three subunits of the ESCRT-I complex (endosomal complexes required for transport) involved in the sorting of ubiquitinated protein. The two other subunits of ESCRT-I are vacuolar protein sorting 23 (VPS23), also known as tumor susceptibility gene 101 (TSG101), and vacuolar protein sorting 37 (VPS37). Two alternative transcripts encoding different isoforms have been described. Additional alternative transcripts may exist but the proteins encoded by these transcripts have not been verified experimentally.^[3]

Interactions

VPS28 has been shown to interact with TSG101.^[4][5][6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)".
4. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
5. Stuchell MD, Garrus JE, Müller B, Stray KM, Ghaffarian S, McKinnon R, Kräusslich HG, Morham SG, Sundquist WI (August 2004). "The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding". J. Biol. Chem. 279 (34): 36059–71. doi:10.1074/jbc.M405226200. PMID 15218037.
6. Bishop N, Woodman P (April 2001). "TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes". J. Biol. Chem. 276 (15): 11735–42. doi:10.1074/jbc.M009863200. PMID 11134028.

Further reading

• Raiborg C, Rusten TE, Stenmark H (2004). "Protein sorting into multivesicular endosomes". Curr. Opin. Cell Biol. 15 (4): 446–55. doi:10.1016/S0955-0674(03)00080-2. PMID 12892785.
• Bishop N, Woodman P (2001). "TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes". J. Biol. Chem. 276 (15): 11735–42. doi:10.1074/jbc.M009863200. PMID 11134028.
• Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (2001). "Protein–Protein Interaction Panel Using Mouse Full-Length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
• Bishop N, Horman A, Woodman P (2002). "Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein–ubiquitin conjugates". J. Cell Biol. 157 (1): 91–101. doi:10.1083/jcb.200112080. PMC 2173266. PMID 11916981.
• Martin-Serrano J, Zang T, Bieniasz PD (2003). "Role of ESCRT-I in Retroviral Budding". J. Virol. 77 (8): 4794–804. doi:10.1128/JVI.77.8.4794-4804.2003. PMC 152150. PMID 12663786.
• Tanzi GO, Piefer AJ, Bates P (2003). "Equine Infectious Anemia Virus Utilizes Host Vesicular Protein Sorting Machinery during Particle Release". J. Virol. 77 (15): 8440–7. doi:10.1128/JVI.77.15.8440-8447.2003. PMC 165230. PMID 12857913.
• Martin-Serrano J, Yarovoy A, Perez-Caballero D, Bieniasz PD, Yaravoy A (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
• Stuchell MD, Garrus JE, Müller B, Stray KM, Ghaffarian S, McKinnon R, Kräusslich HG, Morham SG, Sundquist WI (2005). "The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding". J. Biol. Chem. 279 (34): 36059–71. doi:10.1074/jbc.M405226200. PMID 15218037.
• Bache KG, Slagsvold T, Cabezas A, Rosendal KR, Raiborg C, Stenmark H (2005). "The Growth-Regulatory Protein HCRP1/hVps37A Is a Subunit of Mammalian ESCRT-I and Mediates Receptor Down-Regulation". Mol. Biol. Cell. 15 (9): 4337–46. doi:10.1091/mbc.E04-03-0250. PMC 515363. PMID 15240819.
• Eastman SW, Martin-Serrano J, Chung W, Zang T, Bieniasz PD (2005). "Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding". J. Biol. Chem. 280 (1): 628–36. doi:10.1074/jbc.M410384200. PMID 15509564.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.