WAPAL

WAPL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4K6J, 5HDT
Identifiers
Aliases	WAPL, FOE, KIAA0261, WAPAL, WAPL cohesin release factor
External IDs	MGI: 2675859 HomoloGene: 41002 GeneCards: WAPL
Gene ontology Molecular function • protein binding Cellular component • cytoplasm • cytosol • intracellular membrane-bounded organelle • microtubule cytoskeleton • cohesin complex • chromosome • nucleoplasm • chromatin • synaptonemal complex • chromosome, centromeric region • nucleus • nuclear cohesin complex Biological process • negative regulation of sister chromatid cohesion • mitotic nuclear division • negative regulation of chromatin binding • positive regulation of fibroblast proliferation • negative regulation of DNA replication • regulation of cohesin loading • cell division • regulation of chromosome segregation • cell cycle • viral process • protein localization to chromatin • response to toxic substance • mitotic sister chromatid cohesion • regulation of chromosome condensation • meiotic chromosome segregation • sister chromatid cohesion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23063	218914
Ensembl	ENSG00000062650	ENSMUSG00000041408
UniProt	Q7Z5K2	Q65Z40
RefSeq (mRNA)	NM_015045 NM_001318328	NM_001004436 NM_001301330
RefSeq (protein)	NP_055860.1 NP_001305257.1	NP_001004436.2 NP_001288259.1
Location (UCSC)	Chr 10: 86.44 – 86.52 Mb	Chr 14: 34.67 – 34.75 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Wings apart-like protein homolog is a protein that in humans is encoded by the WAPAL gene.^[3][4][5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
4. Gandhi R, Gillespie PJ, Hirano T (Dec 2006). "Human Wapl Is a Cohesin-binding Protein that Promotes Sister Chromatid Resolution in Mitotic Prophase". Curr Biol. 16 (24): 2406–17. doi:10.1016/j.cub.2006.10.061. PMC 1850625. PMID 17112726.
5. "Entrez Gene: WAPAL wings apart-like homolog (Drosophila)".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Oikawa K, Ohbayashi T, Kiyono T, et al. (2004). "Expression of a novel human gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis and tumor progression". Cancer Res. 64 (10): 3545–9. doi:10.1158/0008-5472.CAN-03-3822. PMID 15150110.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Kwiatkowski BA, Ragoczy T, Ehly J, Schubach WH (2004). "Identification and cloning of a novel chromatin-associated protein partner of Epstein-Barr nuclear protein 2". Exp. Cell Res. 300 (1): 223–33. doi:10.1016/j.yexcr.2004.06.028. PMID 15383329.
• Kuroda M, Oikawa K, Ohbayashi T, et al. (2005). "A dioxin sensitive gene, mammalian WAPL, is implicated in spermatogenesis". FEBS Lett. 579 (1): 167–72. doi:10.1016/j.febslet.2004.11.070. PMID 15620708.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Kueng S, Hegemann B, Peters BH, et al. (2007). "Wapl controls the dynamic association of cohesin with chromatin". Cell. 127 (5): 955–67. doi:10.1016/j.cell.2006.09.040. PMID 17113138.
• Ohbayashi T, Oikawa K, Yamada K, et al. (2007). "Unscheduled overexpression of human WAPL promotes chromosomal instability". Biochem. Biophys. Res. Commun. 356 (3): 699–704. doi:10.1016/j.bbrc.2007.03.037. PMID 17382297.